Results 241 to 250 of about 78,401 (264)
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2010
Disintegrins represent a class of low molecular weight, Arg-Gly-Asp(RGD)/Lys-Gly-Asp(KGD)-containing, cysteine-rich polypeptides derived from venoms of various viper snakes. They bind to various integrins (e.g. αIIbβ3, αvβ3, α5β1 and others) expressed on cell membrane surface, with various degrees of affinity and specificity.
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Disintegrins represent a class of low molecular weight, Arg-Gly-Asp(RGD)/Lys-Gly-Asp(KGD)-containing, cysteine-rich polypeptides derived from venoms of various viper snakes. They bind to various integrins (e.g. αIIbβ3, αvβ3, α5β1 and others) expressed on cell membrane surface, with various degrees of affinity and specificity.
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Structure-Function Correlations of Snake Venom Disintegrins&#
Current Pharmaceutical Design, 2005Disintegrins represent a family of polypeptides released in the venoms of Viperidae and Crotalidae snakes (vipers and rattlesnakes) by the proteolytic processing of multidomain metalloproteinases, which selectively block the function of beta(1) and beta(3) integrin receptors.
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Regulation of the proteolytic disintegrin metalloproteinases, the ‘Sheddases’
Seminars in Cell & Developmental Biology, 2009The proteolytically functional ADAMs, of which there are 13 in the human, play key roles in the way that many different types of cells respond to their environment. They act as 'signalling scissors' within various membrane environments, including at the cell surface, orchestrating rapid changes in the status of their transmembrane protein substrates ...
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1997
Snake venoms contain a complex mixture of pharmacologically active peptides and proteins which have many biological activities. Venoms of the Elapidae and Hydrophiidae families are neurotoxic, whereas those from Viperidae and Crotalidae species cause death by either intravascular clotting or systemic and local hemorrhage.1 Predominant in the group of ...
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Snake venoms contain a complex mixture of pharmacologically active peptides and proteins which have many biological activities. Venoms of the Elapidae and Hydrophiidae families are neurotoxic, whereas those from Viperidae and Crotalidae species cause death by either intravascular clotting or systemic and local hemorrhage.1 Predominant in the group of ...
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[Disintegrins: potent inhibitors of platelet aggregation].
Recenti progressi in medicina, 1995Disintegrins are a family of highly homologous polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide acts as an integrin recognition sequence; it is also present on several proteins involved in cell adhesion such as fibrinogen, fibronectin, von Willebrand factor, and collagen ...
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New Insights into Disintegrin Metalloproteases
Inflammation Research, 1999T. J. Carty +4 more
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