Results 201 to 210 of about 1,416,299 (239)

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Advanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang, Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Chae Eun Jin, Dae Hwan Shin   +5 more
wiley   +1 more source

Programmed Interfacial Phase Separation for Spatiotemporal Fungicide Delivery via Tunable Micro/Nano Architectures

Advanced Science, EarlyView.
ABSTRACT Translating dynamic liquid‐liquid phase separation into robust solid‐state architectures remains a challenge in materials engineering. Here, we report a composition‐driven interfacial assembly strategy that couples supramolecular coacervation with metal‐phenolic coordination to engineer tunable fungicide carriers.
Rui Zhang, Tongfang Jing, Leiming He, Kaidi Cui, Yuying Song, Xuewei Mao, Lidong Cao, Lin Zhou   +7 more
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Ultrafast Chemical Pre‐Sodiation of Pseudocapacitive CaV8O20 Anodes for High‐Performance Sodium‐Ion Capacitors

Advanced Science, EarlyView.
An ultrafast (2‐minute), gas‐free chemical pre‐sodiation strategy using Na‐benzophenone is developed to compensate for initial sodium loss in calcium vanadate (CaV8O20). Driven by the Ca2+ ‘spectator effect’, the framework enables highly reversible, quasi‐zero‐strain solid‐solution sodium storage, explicitly bypassing destructive conversion reactions ...
Neetu Bansal, Anwar Hussain, Radhey Shyam Yadav, Prakash Kumar Pathak, Minjoong Kim, Tobias Mattisson, Heejoon Ahn, Rahul R. Salunkhe   +7 more
wiley   +1 more source

Activating Ionic Carbon Nitrides via Epitaxial Dyadic Coupling for Efficient Solar‐Driven H2O2 Generation

Advanced Science, EarlyView.
Epitaxial integration of a C1N1 phase onto KPHI creates a dyadic charge‐transfer nanostructure with strong interfacial electronic coupling. This architecture drives directional electron transfer from KPHI to C1N1, enabling efficient cocatalyst‐free solar H2O2 production.
Haijian Tong, Chenyan Zhao, Christian Mark Pelicano, Markus Antonietti   +3 more
wiley   +1 more source

Assessing the colony morphotypes and antibiotic susceptibility profile of Malaysian clinical Burkholderia pseudomallei to support the use of EUCAST disk diffusion breakpoints to determine antibiotic resistance. [PDF]

Eur J Clin Microbiol Infect Dis
Hii SYF, Zaiful Bahrina NN, Mohd Zaidi MN, Hashim R, Ahmad N.   +4 more
europepmc   +1 more source