Results 51 to 60 of about 597,728 (330)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Internal splintage of acute acromioclavicular joint dislocation using polyester suture: Experience from a Nigerian orthopaedic hospital

Nigerian Postgraduate Medical Journal, 2022
Background: Various surgical options have been described for acute acromioclavicular joint (ACJ) disruption. Dynamic fixation of these fractures is the most favoured option. However, no single modality of treatment has been adjudged to be the best option
Arojuraye Soliudeen Adebayo, Alabi Ibrahim Abolaji, Mustapha Ibrahim Usman   +2 more
doaj   +1 more source

Intermittent dislocation density fluctuations in crystal plasticity from a phase-field crystal model

, 2014
Plastic deformation mediated by collective dislocation dynamics is investigated in the two-dimensional phase-field crystal model of sheared single crystals.
Angheluta, Luiza, Goldenfeld, Nigel, Mathiesen, Joachim, Tarp, Jens M.   +3 more
core   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Isolated Dislocation of the Distal Radio-Ulnar Joint: An Unrecognized Emergency

The Annals of African Surgery, 2020
Dislocation of the isolated distal radioulna joint (DRUJ) is rare. The clinical and radiological signs are not suggestive, making diagnosis difficult and sometimes late. Care remains disparate for both recent and neglected forms.
Ralahy Fanjalalaina, Randimbinirina Zakarimanana, Andrianimaro Florelia, Rohimpitiavana Amboara, Razafimahandry Henri   +4 more
doaj  

Microstructure versus size: nano/microscale deformation of solute-strengthening Al alloys via pillar compression tests

Materials Research Letters, 2019
Effect of solutes, crystal orientation, sample’s size, and dislocation density on the nano/microscale deformation of solute-strengthening Al alloys has been investigated via pillar compression tests.
Shaohua Yan, Haiyang Zhou, Qing H. Qin
doaj   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Micro-plasticity and intermittent dislocation activity in a simplified micro structural model

, 2013
Here we present a model to study the micro-plastic regime of a stress-strain curve. In this model an explicit dislocation population represents the mobile dislocation content and an internal shear-stress field represents a mean-field description of the ...
, Abramowitz M, Argon A S, Bulatov V V, Devincre B, Hull D, Ispánovity P D, Kuhlmann-Wilsdorf D, Lebyodkin M A, Nabarro F R N, Neuhäuser H, P M Derlet, R Maaß, Van der Giessen E, Weygand D   +14 more
core   +1 more source

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

A model for frictional sliding instability on a heterogeneous fault

Annals of Geophysics, 1994
An instability of frictional sliding driven by tectonic stress is assumed to be the source of earthquakes. Empirical slip laws indicate that, under constant ambient conditions, friction depends on time, slip rate and slip history.
A. Piombo, M. Dragoni
doaj   +1 more source