Results 231 to 240 of about 5,886,495 (367)

Tinnitus and tinnitus disorder: Genetic, neurobiological, and clinical differentiation. [PDF]

iScience
De Ridder D, Kleinjung T, Song JJ, Adhia D, Hall M, Yasoda-Mohan A, Vanneste S, Londero A, Weisz N, Schlee W, Elgoyhen AB, Cederroth C, Lopez-Escamez JA, Gallus S, Schoisswohl S, Sedley W, Searchfield G, Park SN, Langguth B.   +18 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Risk of all-cause and cause-specific mortality, and suicide attempt in people with anxiety and stress-related disorders: a systematic review, meta-analysis and meta-regression analysis of 165 studies. [PDF]

World Psychiatry
Wagner E, Mortazavi M, Poddighe L, Baldwin DS, Masdrakis V, Castle DJ, Serretti A, Oliva V, Fanelli G, Fornaro M, Shin JI, Colman I, Semchishen SN, Anderson KK, Wang JL, Brietzke E, Sabé M, Cortese S, Domschke K, Hasan A, Chang WC, Myran DT, Correll CU, Connor Gorber S, Højlund M, Solmi M.   +25 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Disorder in van der Waals heterostructures of 2D materials

Nature Materials, 2019
D. Rhodes, S. Chae, R. Ribeiro-Palau, J. Hone   +3 more
semanticscholar   +1 more source

"It Was Like They'd Lit a Fuse": A Mixed-Methods Investigation Into Rage. [PDF]

Aggress Behav
Denson TF, Harmon-Jones E, Larsson J, Curtis A, Harries T, Miller PG.   +5 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

How is EMDR best conducted and adapted for trauma-focused work within bipolar disorder? A Delphi study. [PDF]

Eur J Psychotraumatol
Nicholls L, Richardson T, Spain D, Wright K.   +3 more
europepmc   +1 more source