Results 251 to 260 of about 5,886,495 (367)

Prediction and functional analysis of native disorder in proteins from the three kingdoms of life.

Journal of Molecular Biology, 2004
J. J. Ward, J. S. Sodhi, L. McGuffin, B. Buxton, David C. Jones   +4 more
semanticscholar   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Delusional disorder and its differentiation from schizophrenia: A narrative review. [PDF]

Psychol Med
Rossi Grauenfels D, Henriksen MG, Nordgaard J.   +2 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Factors influencing delays in the diagnosis and treatment of bipolar disorder in adolescents and young adults: systematic scoping review. [PDF]

BJPsych Open
Levit A, Lam F, Nunez JJ, Morton E, Keramatian K.   +4 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Structured lasing with disordered high-<i>Q</i> perovskite cavities. [PDF]

Sci Adv
Zhou Z, Wang S, Wen W, Qin J, Chen W, Tan J, Wang Z, Huang L, Chen J, Jiang L, Feng J, Qiu CW.   +11 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Digital CBT reduces mental disorders and boosts access to care in college students. [PDF]

Nat Hum Behav
europepmc   +1 more source

Schizophrenia and bipolar disorder: a comparative analysis of genetic and brain network connectivity. [PDF]

Psychol Med
Ren H, Liu Y, Huang Y, Tang Y, Xiao L, Wu Y, Liu S, Yin Y, Ma Q, Dai M, Tao S, Xie M, Li M, Li T, Wang Q.   +14 more
europepmc   +1 more source