Results 61 to 70 of about 5,552,271 (346)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Downregulation of the HCN1 Channel Alleviates Anxiety‐ and Depression‐Like Behaviors in Mice With Cerebral Ischemia–Reperfusion Injury by Suppressing the NLRP3 Inflammasome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Post‐stroke depression (PSD) is a prevalent neuropsychiatric complication of stroke. However, the mechanisms underlying PSD are still unclear.
Mei Zhou, Xiaoqin Tao, Kuan Lin, Changlong Leng, Youhua Yang, Yuran Gui, Yaojian Sun, Meiling Zhou, Binlian Sun, Yiyuan Xia, Xiji Shu, Wei Liu   +11 more
doaj   +1 more source

Loss of the neurodevelopmental disease-associated gene miR-146a impairs neural progenitor differentiation and causes learning and memory deficits

Molecular Autism, 2020
Background Formation and maintenance of appropriate neural networks require tight regulation of neural stem cell proliferation, differentiation, and neurogenesis.
Julien Fregeac, Stéphanie Moriceau, Antoine Poli, Lam Son Nguyen, Franck Oury, Laurence Colleaux   +5 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Neurodevelopmental disorders [PDF]

The Lancet Psychiatry, 2017
Neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder, although most commonly considered in childhood, can be lifelong conditions. In this Personal View that is shaped by clinical experience and research, we adopt a conceptual approach.
Thapar, Anita, Cooper, Miriam, Rutter, Michael   +2 more
openaire   +4 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Development and usability testing of ‘my symptoms young’: a web-based self-help program for persistent physical symptoms in adolescents (part of the eASY research programme)

BMC Digital Health
Background Persistent physical symptoms (PPS) (i.e., symptoms that cannot be explained by conventional diagnoses) are common in young people. PPS are associated with impairments in daily life activities, mental health problems and low quality of life. In
Oliver Rønn Christensen, Lisbeth Frostholm, Mette Trøllund Rask, Marianne Rosendal, Charlotte Ulrikka Rask   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Investigating the relationship between asthma symptoms and severity with television watching, computer use, and internet access among 13-14-year-old children in Yazd, Iran

BMC Pediatrics
Background Asthma is a prevalent chronic respiratory disease that affects individuals from childhood to adulthood. This study aimed to investigate the association between symptoms and severity of asthma with television viewing, computer and Internet use ...
Nasrin Behniafard, Zahra Nafei, Foad Forghani, Masoud Faisal, Mehran Karimi, Marzie Vaghefi   +5 more
doaj   +1 more source

IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding

Nucleic Acids Res., 2018
The structural states of proteins include ordered globular domains as well as intrinsically disordered protein regions that exist as highly flexible conformational ensembles in isolation.
Bálint Mészáros, Gábor Erdös, Z. Dosztányi   +2 more
semanticscholar   +1 more source