Results 61 to 70 of about 3,889,659 (236)

Infinite disorder and correlation fixed point in the Potts model with correlated disorder

, 2016
Recent Monte Carlo simulations of the q-state Potts model with a disorder displaying slowly-decaying correlations reported a violation of hyperscaling relation caused by large disorder fluctuations and the existence of a Griffiths phase, as in random ...
Chatelain, Christophe
core   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Protecting clean critical points by local disorder correlations

, 2011
We show that a broad class of quantum critical points can be stable against locally correlated disorder even if they are unstable against uncorrelated disorder.
Hoyos, J. A., Laflorencie, Nicolas, Vieira, A. P., Vojta, Thomas   +3 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

B(H) Constitutive Relations Near H_c1 in Disordered Superconductors

, 1999
We provide a self-contained account of the B vs. H constitutive relation near H_c1 in Type II superconductors with various types of quenched random disorder.
Barabási, Blatter, Bolle, Budhani, Carpentier, Civale, Civale, David R. Nelson, deGennes, Deligiannis, Devereaux, Fetter, Finnemore, Fisher, Fisher, Forster, Frey, Friedberg, Fuchs, Gerhäuser, Halpin-Healy, Halpin-Healy, Hardy, Hardy, Hatano, Hatano, Hwa, Hwa, Hwa, Ioffe, Janssen, Kardar, Kardar, Kardar, Khaykovich, Khaykovich, Kierfeld, Konczykowski, Krusin-Elbaum, Krusin-Elbaum, Larkin, Le Doussal, Lehrer, Li, Lifshits, Marchetti, Medina, Nattermann, Nelson, Nelson, Nelson, Nelson, Nelson, Raphael A. Lehrer, Serin, Tinkham, Täuber, Zittarz   +57 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Quantum Walks on Trees with Disorder: Decay, Diffusion, and Localization

, 2012
Quantum walks have been shown to have impressive transport properties compared to classical random walks. However, imperfections in the quantum walk algorithm can destroy any quantum mechanical speed-up due to Anderson localization.
A. Ambainis, A. M. Childs, Frederick W. Strauch, Steven R. Jackson, Teng Jian Khoo   +4 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source