Results 71 to 80 of about 309,282 (333)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The Effect of Self-Focused Attention on Psychopathology [PDF]

, 1997
This study investigated whether self-focused attention is related to psychopathology in general or if, instead, specific types of self-focus are associated with specific disorders.
Payne, Keith
core   +1 more source

Update on neuroimaging in disorders of consciousness

Current Opinion in Neurology, 2021
Purpose of review Neuroimaging has acquired a prominent place in the assessment of disorders of consciousness (DoC). Rapidly evolving technologies combined with state-of-the-art data analyses open new horizons to probe brain activity, but selecting ...
L. Sanz, A. Thibaut, B. Edlow, S. Laureys, O. Gosseries   +4 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The sleep cycle: a mathematical analysis from a global workspace perspective [PDF]

, 2005
Dretske's technique of invoking necessary conditions from information theory to describe mental process can be used to derive a version of Hobson's AIM treatment of the sleep/wake cycle from a mathematical formulation of Baars' Global Workspace model of ...
Wallace, Rodrick
core  

Cerebral Glucose Metabolism in Patients with Chronic Disorders of Consciousness

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2022
: Objective: To measure regional cerebral metabolic rate of glucose (CMRGlu) in patients with chronic disorders of consciousness (DOCs) using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). Methods: This retrospective cohort study examined
Noriko Usami, Y. Asano, Y. Ikegame, Hiroaki Takei, Y. Yamada, H. Yano, J. Shinoda   +6 more
semanticscholar   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

Comprehensive systematic review update summary: Disorders of consciousness

Neurology, 2018
Objective To update the 1995 American Academy of Neurology (AAN) practice parameter on persistent vegetative state and the 2002 case definition for the minimally conscious state (MCS) by reviewing the literature on the diagnosis, natural history ...
J. Giacino, D. Katz, N. Schiff, J. Whyte, E. Ashman, S. Ashwal, R. Barbano, F. Hammond, Steven Laureys, G. Ling, R. Nakase-Richardson, R. Seel, S. Yablon, Thomas S. D. Getchius, G. Gronseth, M. Armstrong   +15 more
semanticscholar   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Psilocybin increases optimistic engagement over time: computational modelling of behaviour in rats

Translational Psychiatry
Psilocybin has shown promise as a novel pharmacological intervention for treatment of depression, where post-acute effects of psilocybin treatment have been associated with increased positive mood and decreased pessimism.
Elizabeth L. Fisher, Ryan Smith, Kyna Conn, Andrew W. Corcoran, Laura K. Milton, Jakob Hohwy, Claire J. Foldi   +6 more
doaj   +1 more source