Results 111 to 120 of about 536,565 (302)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

TORSIONAL WAVE SCATTERING IN TWO-LAYER PIPE WITH ACCOUNT FOR CONTACT RIGIDITY

Известия высших учебных заведений России: Радиоэлектроника, 2018
The purpose of the paper is to study the wave propagation in a two-layer pipe, taking into account the rigidity of the contact between its layers. It is considered by solving the equation of motion for the vector and scalar potentials.
Konstantin E. Abbakumov, Nikolay V. Stepanenko   +1 more
doaj   +1 more source

Fast Radio Bursts: Constraints on the Dispersing Medium

, 2014
Fast radio bursts appear to exhibit large dispersion measures, typically exceeding any expected galactic interstellar contribution, especially along the moderate to high-galactic-latitude directions in which such events have been most often observed. The
Dennison, Brian
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Hysteretic response characteristics and dynamic phase transition via site dilution in the kinetic Ising model

, 2012
The decay of the hysteresis loop area of the system, which is obeying a site diluted kinetic Ising model, is considered by the disorder parameter using the effective field theory analysis.
Acharyya, Acharyya, Acharyya, Acharyya, Acharyya, Agarwal, Angst, B.O. Aktaş, Balcerzak, Berkoilako, Binder, Bruno, Chakrabarti, Deviren, Fan, Gilmore, Glauber, Gunton, H. Polat, Honmura, Idigoras, Jiang, Jung, Kaneyoshi, Kaneyoshi, Kaneyoshi, Kanuga, Korniss, Liu, Liu, Lo, Luse, Lyuksyutov, Mayergoyz, Nattermann, Nattermann, Nowak, Punya, Rao, Robb, Shi, Shi, Sides, Steinmetz, Suen, Suzuki, Tomè, Tucker, Zernike, Zhu, Ü. Akıncı   +50 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

New Torsional Surface Elastic Waves in Cylindrical Metamaterial Waveguides for Sensing Applications

Sensors
In this paper, we demonstrate that torsional surface elastic waves can propagate along the curved surface of a metamaterial elastic rod (cylinder) embedded in a conventional elastic medium.
Piotr Kiełczyński, Krzysztof Wieja, Andrzej Balcerzak   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Determination of surface-wave phase velocities by zeros of Aki’s spectrum of active-source records: Application to the dense array in Tongzhou, ChinaKey points

Earthquake Science
The spatial autocorrelation (SPAC) (also known as the Aki’s spectral method) of ambient seismic noise has been widely adopted in surface wave phase velocity extraction.
Qinghua Liu, Laiyu Lu, Tongwei Qin, Lijun Chang   +3 more
doaj   +1 more source

Disperse: A General Purpose Program for Creating Dispersion Curves

, 1997
The application of guided waves in NDT can be hampered by the lack of readily available dispersion curves for complex structures. To overcome this hindrance, we have developed a general purpose program that can create dispersion curves for a very wide range of systems and then effectively communicate the information contained within those curves.
Pavlakovic, Brian, Lowe, Mike, Alleyne, David, Cawley, Peter   +3 more
openaire   +3 more sources