Results 41 to 50 of about 1,532,382 (286)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Synthesis of the refractive index profile of the optical fiber with the account of Kerr nonlinearity

open access: yesФизика волновых процессов и радиотехнические системы, 2018
In the present paper, we investigate the possibilities of reducing the distortions of propagated in optical fibers high-power femtosecond pulses due to the choice of its refractive index profile, taking into account the profile changes due to the cubic ...
V.A. Burdin, A.V. Bourdine
doaj  

Design of photonic crystal fibers with flat dispersion and three zero dispersion wavelengths for coherent supercontinuum generation in both normal and anomalous regions

open access: yesResults in Physics, 2021
A photonic crystal fiber (PCF) structure with three-zero dispersion wavelengths (ZDWs) and a flat dispersion curve was designed by adjusting the structural parameters (the diameters of small air holes inserted between standard lattices in the first and ...
Ying Huang   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Parametric evaluation of 3D dispersion of rockfall trajectories [PDF]

open access: yesNatural Hazards and Earth System Sciences, 2004
The capability of evaluating and managing rockfall related risks is largely based on numerical modelling. Nevertheless, the reliability and accuracy of rockfall models is greatly affected by the strong uncertainty and spatial variability which ...
G. B. Crosta, F. Agliardi
doaj  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Dispersion Compensating Photonic Crystal Fiber with Enhanced Properties Achieved by Modified Core Geometry

open access: yesAdvances in Electrical and Electronic Engineering, 2012
A novel dispersion compensating fiber based on photonic crystal fiber has been designed and studied in terms of optimal dispersion and operating bandwidth.
Stanislav Kraus, Michal Lucki
doaj   +1 more source

Double Feature Extraction Method of Ship-Radiated Noise Signal Based on Slope Entropy and Permutation Entropy

open access: yesEntropy, 2021
In order to accurately identify various types of ships and develop coastal defenses, a single feature extraction method based on slope entropy (SlEn) and a double feature extraction method based on SlEn combined with permutation entropy (SlEn&PE) are ...
Yuxing Li   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

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