Results 161 to 170 of about 1,971 (208)

Photoredox-enabled late-stage functionalization of pyrrolidines in batch and flow: rapid access to benzothiazole hybrids as a new class of cholinesterase inhibitors. [PDF]

RSC Adv
Filipović A, Vučkovski M, Mićović D, Bondžić AM, Bondžić BP.   +4 more
europepmc   +1 more source

Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance. [PDF]

Sci Adv
Klope MT, Talukder P, Blank BR, Chelebieva S, Chen J, Fontaine SD, Gonciarz RL, Jaishankar P, Lee GJ, Legac J, Mathur V, Narayan A, Okitwi M, Orena S, Settineri NS, Tapia JA, Taremwa Y, Tumwebaze PK, Vinod A, Burrows JN, Rosenthal PJ, Cooper RA, Renslo AR.   +22 more
europepmc   +1 more source

1,3-Dipolar Cycloaddition of Nitrile Imines and Nitrile Oxides to Exocyclic C=N Bonds-An Approach to <i>Spiro</i>-N-Heterocycles. [PDF]

Int J Mol Sci
Petrova JV, Kukushkin ME, Beloglazkina EK.   +2 more
europepmc   +1 more source

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Highly Efficient and Stereoselective Construction of Dispiro-[oxazolidine-2-thione]bisoxindoles and Dispiro[imidazolidine-2-thione]bisoxindoles

Organic Letters, 2012
An efficient and stereoselective reaction between 3-isothiocyanato oxindoles and isatins/isatinimines has been developed to afford structurally diverse dispiro[oxazolidine-2-thione]bisoxindoles and dispiro[imidazolidine-2-thione]bisoxindoles in excellent results under mild conditions. The potential of asymmetric induction by means of a chiral auxiliary
Wen-Yong Han, Wei-Cheng Yuan
exaly   +3 more sources

Piperidine dispiro-1,2,4-trioxane analogues

Bioorganic & Medicinal Chemistry Letters, 2008
Dispiro N-Boc-protected 1,2,4-trioxane 2 was synthesised via Mo(acac)(2) catalysed perhydrolysis of N-Boc spirooxirane followed by condensation of the resulting beta-hydroperoxy alcohol 10 with 2-adamantanone. N-Boc 1,2,4-trioxane 2 was converted to the amine 1,2,4-trioxane hydrochloride salt 3 which was subsequently used to prepare derivatives (4-7 ...
Sunil, Sabbani, Paul A, Stocks, Gemma L, Ellis, Jill, Davies, Erik, Hedenstrom, Stephen A, Ward, Paul M, O'Neill   +6 more
openaire   +3 more sources

Synthesis and rearrangement of dispiro[3.1.3.2]-, dispiro[3.0.3.3]- and dispiro[3.0.4.2]undecanes- new entries to [3.3.3]propellanes

Tetrahedron, 1994
Abstract The dispiroketones 4–6 have been synthesized and rearranged by treatment with acids yielding the bicyclic enone 36 under kinetic control and the [3.3.3]propellane 37 under thermodynamic control. The corresponding alcohols 10–12 all yield the [3.3.3]propellane 41. The rearrangement of [7,7-D2]-12 to [8,8-D2]-41 proceeds stereospecifically and
Lutz Fitjer, Andrew Kanschik, Marita Majewski   +2 more
openaire   +1 more source

New Dispiro Compounds:  Synthesis and Properties

Organic Letters, 2008
We report the synthesis and structural characterization of two dispiro compounds. These two positional isomers have been designed and synthesized through an efficient method. Because of the rigidity and orthogonality of the spiro bridge, both molecules exhibit a well-defined architecture which consists of two fluorene rings connecting to an ...
Poriel, Cyril, Rault-Berthelot, Joëlle, Barrière, Frédéric, M. Z. Slawin, Alexandra   +3 more
openaire   +2 more sources