Results 91 to 100 of about 928,593 (318)

Profiling IDP populations: new guidelines [PDF]

open access: yesForced Migration Review, 2007
The lack of reliable IDP information has long hinderedeffective responses to internal displacement situations.The ‘Guidance on Profiling Internally Displaced Persons’is a new tool designed to assist humanitarian actors inconducting IDP surveys.
Jens-Hagen Eschenbächer, Tom Delrue
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Biofilms as potential reservoirs of antimicrobial resistance in vulnerable settings

open access: yesFrontiers in Public Health
Antimicrobial resistance is a major global health threat, characterized by the ability of microorganisms to withstand the effects of antimicrobial agents. Biofilms, as unique microbial communities, significantly contribute to this threat.
Yanina Nahum   +7 more
doaj   +1 more source

Dubai: a City of Hope? [PDF]

open access: yesForced Migration Review, 2007
The City of Hope is an organisation offering refuge for abused women in Dubai, the largest city of the United Arab Emirates. Dubai has started to acknowledge the social problems accompanying its phenomenal economic growth but is it doing enough to tackle
Lina Abirafeh
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

The measurement of the absolute displacement of a noisy disc brake

open access: yes, 2008
The investigation of in-plane vibration of a noisy disc brake is problematic because it is difficult both to measure and to verify. Because of the disc structure and the inability to visualize disc in-plane vibration, there has been reluctance by ...
Talbot, Chris J.   +5 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Wages and the risk of displacement [PDF]

open access: yes
In this paper a simultaneous-equations model of firm closing and wage determination is specified in order to analyse how wages adjust to unfavorable product demand shocks that raise the risk of displacement through firm closing, and to what extent an ...
Carneiro, Anabela, Portugal, Pedro
core  

Extending displacement-based earthquake loss assessment (DBELA) for the computation of fragility curves

open access: yes, 2012
This paper presents a new procedure to derive fragility functions for populations of buildings that relies on the displacement-based earthquake loss assessment (DBELA) methodology.
SILVA MOURA PINHO, RUI JORGE   +7 more
core   +1 more source

Pastoralists in Kenya [PDF]

open access: yesForced Migration Review, 2008
The pastoralist community of northern Kenya has been ravaged by both droughts and floods.
Mohamed Adow
doaj  

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