Results 101 to 110 of about 928,593 (318)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Electing Displacement: Political Cleansing in Apartadó, Colombia [PDF]
This article highlights a nefarious effect of elections during civil wars by demonstratingthat they can facilitate the displacement of civilians. This occurs through two main mechanisms: they reveal information about civilians' loyalties directly to ...
Abbey Steele
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Forced Displacement : Moving from Managing Risk to Facilitating Opportunity
, 2013 Displacement is most commonly perceived as a situation of crisis; a time in which risks to the displaced and to host communities need to be mitigated and managed.
Lakhani, Sadaf
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Preventing and preparing for disaster displacement
, 2020 Examples of good practice relating to preventing, mitigating and preparing for disaster displacement, discussed as part of the GP20 initiative, have revealed valuable lessons on early action, data, laws and policies, and community ...
Essig, Barbara +2 more
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
A is B, displacement: Exploring linking patterns within metaphor in the design process
, 2011 Design educators often apply metaphor as a teaching tool to help novice designers in their design process. Richards(1936) defines metaphor as the form “A is Bi. The most important operation in metaphor is displacement “ the linking process of moving A to
T.W. Chang, I.C. Lai, C.H. Lo
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