Results 141 to 150 of about 3,009,655 (375)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Ethical considerations for a more equitable approach to One Health in forced migration

open access: yesCABI One Health
Background: The exclusion of animals from humanitarian responses to forced migration out of concern for the transmission of zoonoses, diseases transmissible between animals and humans, leads to risk taking and trade-offs, whereby forced migrants choose ...
Dr Dorien Hanneke Braam
doaj   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

open access: yesMolecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti   +3 more
wiley   +1 more source

Perbandingan Respon Dinamis Pada Struktur Bangunan Bertingkat Tidak Beraturan Dengan Tiga Varian Konfigurasi Dinding Geser

open access: yesTeras Jurnal: Jurnal Teknik Sipil
Abstrak   Artikel ini menyajikan hasil perbandingan respon struktur terhadap 3 variasi konfigurasi dinding geser pada bangunan bertingkat yang tidak beraturan pada denah.
mukhammad nailul muna, Mochamad Teguh
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Brazilian trafficking: soap opera versus reality [PDF]

open access: yesForced Migration Review, 2006
More than a hundred years after slavery was formally abolished in Brazil, a modern-day version thrives.
Luciana Campello R Almeida   +2 more
doaj  

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