Results 131 to 140 of about 1,465,211 (311)

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Influence Mechanism of N₂-CO₂ Mixtures on the CH₄ Displacement Behavior from Different Coal Samples under Stress Condition. [PDF]

ACS Omega
Li Y, Lv R, Qiao L, Yang X, Wu H, Wang X.   +5 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Smooth constrained block matching algorithm for the evaluation of diaphragm deformation in speckle-tracking ultrasound. [PDF]

Front Med (Lausanne)
Li Q, Zhang P, Ye X, Liu Q.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Efficient distribution of tuned mass dampers for seismic control in regular and irregular multi-story steel buildings. [PDF]

Sci Rep
Shabib MM, Farag HM, Khalifa YA, Zahran MS.   +3 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Effects of proactive or synchronous anchorage preparation of posterior teeth during anterior en masse retraction with clear aligners: a three-dimensional finite element study. [PDF]

Prog Orthod
Li R, Shi W, Li Y, Zhu Z, Ouyang N, Duan Y, Mei P, Jiang T, Chen X, Qu L, Ding Z, Liu C, Yang Z, Jin Y, Zhu C, Jing D, Xia L.   +16 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Finite element analysis of impacted canine disimpaction: effects of anchorage systems and T-loop gable bend angles. [PDF]

Front Bioeng Biotechnol
Li X, Li X, Yu S, Zhang Y, Yang W, Guo J, Jiang X, Yan X, Zhang Q, Yuan X.   +9 more
europepmc   +1 more source