Results 71 to 80 of about 1,132,423 (301)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Numerical Modeling of Particles Separation Method Based on Compound Electric Field

Applied Sciences, 2020
This paper shows the results of simulation of features and usability of a proposed method for particle matter (PM) separation detection based on composite electric field.
Min Wang, Junchen Zou, Hongli Zhang, Yuan Wei, Shulin Liu   +4 more
doaj   +1 more source

Electrically driven octahedral rotations in SrTiO3 and PbTiO3

, 2012
We investigate the oxygen octahedral rotations that occur in two perovskites, SrTiO3 and PbTiO3, as a function of applied three-dimensional electric displacement field, allowing us to map out the phase diagram of rotations in both the paraelectric and ...
Hong, Jiawang, Vanderbilt, David
core   +1 more source

Mean Field Games Systems under Displacement Monotonicity

SIAM Journal on Mathematical Analysis
to appear in SIAM J.
Mészáros, Alpár R., Mou, Chenchen
openaire   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Stress Intensity Factor calculation from displacement fields

Frattura ed Integrità Strutturale, 2017
In the last two decades, visual image techniques such as Digital Image Correlation (DIC) enabled to experimentally determine the crack tip displacement and strain fields at small scales. The displacements are tracked during loading, and parameters as the Stress Intensity Factor (SIF), opening and closing loads, T-stress can be readily measured.
Beretta, S., Patriarca, L., Rabbolini, S.   +2 more
openaire   +5 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

DIC-Based Hydration Absorption Detection and Displacement Field Evolution of Outcrop Porous Sandstone

Applied Sciences
In order to study the hydration absorption behaviors and characteristics of sandstone in Mogao Grottoes in China, the pressure-less hydration absorption experiment on the outcrop porous sandstone of Mogao Grottoes was carried out by using the self ...
Nai Hao, Yongliang Wang, Yi Zhao, Wujie Jiang, Panshun Li, Nana Liu   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis Frequencies of a Vibration-Type Structure Hall

The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2014
Its main purpose was to identify natural vibration frequencies for a warehouse type structure in order to avoid resonance phenomena of the structure. The analysis is performed using the finite element analysis module of the CATIA system.
Ionel PETREA
doaj