Results 91 to 100 of about 95,850 (268)
Investigation of Hatay-Defne earthquake (20.02.2023) by using GNSS station
Geodesy and CartographyNo studies have been conducted on the spatial changes related to the Hatay-Defne earthquake (20 February 2023) up to now. The reason for this situation is that the requested data cannot be accessed as a result of the power and internet interruptions ...
Atınç Pırtı +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Calculation models of beams with one-way connections
Вестник Дагестанского государственного технического университета: Технические наукиObjective. The article considers the operational features of beam structures with one-way ties. Method. By studying the operational features of beam structure supports, analytical and graphical dependencies between beam displacements and their support ...
A. K. Yusupov +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Engineering Structures and Technologies, 2018 The article presents the results of the numerical analysis of the asymmetrical one-pylon suspension bridge built-in rigid cables. The models for the suspension bridge with the cables of different rigidity are analyzed by comparing vertical displacements,
Tatjana Grigorjeva, Ainars Paeglitis
doaj
LOAD TESTING OF THE SVILAJ INTERSTATE BRIDGE
e-Zbornik. Elektronički Zbornik Radova Građevinskog FakultetaThe paper presents static and dynamic load testing of the Svilaj interstate bridge over the Sava River. In addition to presenting the basic structural elements of the bridge, the paper briefly describes the testing method, provides the basic ...
Mladen Kustura +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source