Results 111 to 120 of about 521,536 (306)
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Journal of Industrial Design and Engineering Graphics, 2016 The laboratory equipment used for testing the impact behavior of plastics uses low impact energies. In the last years were developed constructive solutions of monobloc pendulums, in order to ensure design and manufacturing simplicity.
Vasile Cojocaru, Gabriel Cacareaza
doaj
Agustín de Betancourt’s Double-Acting Steam Engine: Analysis through Computer-Aided Engineering
Applied Sciences, 2018 This article analyses the double-acting steam engine designed by Agustín de Betancourt in 1789 and based on the steam engine of James Watt. Its novelty and scientific interest lies in the fact that from the point of view of industrial archaeology and the
José Ignacio Rojas-Sola +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Key-in-hand or Self-managed Production? Socio-urban Effects of Public Policies for Popular Housing
Íconos, 2016 Public access to housing for the popular sectors has set up, in the last years, as one of the most pressing problems due to the segregating effects that it brings. This paper compares and evaluates the results of the new social housing production policy (
María Cecilia Zapata
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Short-term evolution of coronal hole boundaries
, 2011 The interaction of open and closed field lines at coronal hole boundaries is widely accepted to be due to interchange magnetic reconnection. To date, it is unclear how the boundaries vary on short timescales and at what velocity this occurs.
Antiochos +10 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source