Results 121 to 130 of about 183,763 (314)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Comparison of Regional Differences in Microsphere Displacements.
, 2016 In both (A) Fixed and (B) Free gels the cumulative displacements of images associated with Region 1 (yellow box) and Region 4 (red box) at each hour are represented with box plots, where the box edges show the 25th and 75th percentiles, the median is ...
Maziar Aghvami (2166142) +2 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Vertical tunnel displacement for various underpinning loads: (a) Vertical displacements; (b) Peak displacements.
Zhenbo Zhang (579190) +7 more
core +1 more source
Universal displacements in linear elasticity
, 2019 In nonlinear elasticity, universal deformations are the deformations that exist for arbitrary strain-energy density functions and suitable tractions at the boundaries. Here, we discuss the equivalent problem for linear elasticity.
Goriely, Alain +2 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
BuildingsThis study analyzes the results of a displacement measurement of the Sungnyemun Gate’s structural members, such as column, girder, and hip rafter, carried out by the National Institute of Cultural Heritage for about 10 years from December 2013 to October
Hyowon Seo, Hana Lee, Sunghan Kim
doaj +1 more source
Decomposed elbow displacements.
, 2019 Mean and error bar of the 5 displacements as function of the flexion angle for fresh specimens with ligaments and dry bone specimens.
Santiago Arroyave-Tobón (6425432) +3 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source