Results 111 to 120 of about 513,826 (300)

Geometrical effects on mobility [PDF]

, 2017
In this paper we analyze the effect of randomly deleting streets of a synthetic city on the statistics of displacements. Our city is constituted initially by a set of streets that form a regular tessellation of the euclidean plane. Therefore we will have
Lopez, Jorge H.
core   +1 more source

How a plantar pressure-based, tongue-placed tactile biofeedback modifies postural control mechanisms during quiet standing

, 2007
The purpose of the present study was to determine the effects of a plantar pressure-based, tongue-placed tactile biofeedback on postural control mechanisms during quiet standing.
A Horstmann, BB Mandelbrot, DA Winter, DA Winter, G Clément, GK Essick, Jacques Demongeot, JJ Collins, L Bernard-Demanze, Matthieu Boisgontier, N Genthon, N Vuillerme, N Vuillerme, N Vuillerme, Nicolas Pinsault, Nicolas Vuillerme, O Caron, O Caron, Olivier Chenu, P Bach-y-Rita, P Rougier, P Rougier, WH Gage, Y Brenière, Y Brenière, Yohan Payan   +25 more
core   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Displacement-enhanced continuous-variable entanglement concentration

, 2012
We study entanglement concentration of continuous variable Gaussian states by local photon subtractions enhanced by coherent displacements. Instead of the previously considered symmetric two-mode squeezed vacuum states, we investigate the protocol for ...
Fiurášek, Jaromír, Černotík, Ondřej   +1 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Short-term evolution of coronal hole boundaries

, 2011
The interaction of open and closed field lines at coronal hole boundaries is widely accepted to be due to interchange magnetic reconnection. To date, it is unclear how the boundaries vary on short timescales and at what velocity this occurs.
Antiochos, Bravo, Chapman, Edmondson, Edmondson, Fisk, Fisk, Madjarska, Schrijver, Wang, Wang   +10 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A Study of Member Displacement According to Seasonal Climate of the Sungnyemun Gate, a Korean Wooden Architectural Heritage Site

Buildings
This study analyzes the results of a displacement measurement of the Sungnyemun Gate’s structural members, such as column, girder, and hip rafter, carried out by the National Institute of Cultural Heritage for about 10 years from December 2013 to October
Hyowon Seo, Hana Lee, Sunghan Kim
doaj   +1 more source