Results 121 to 130 of about 513,826 (300)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Investigation of Hatay-Defne earthquake (20.02.2023) by using GNSS station

Geodesy and Cartography
No studies have been conducted on the spatial changes related to the Hatay-Defne earthquake (20 February 2023) up to now. The reason for this situation is that the requested data cannot be accessed as a result of the power and internet interruptions ...
Atınç Pırtı, Zümrüt Kurtulgu, Mehmet Eren   +2 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Calculation models of beams with one-way connections

Вестник Дагестанского государственного технического университета: Технические науки
Objective. The article considers the operational features of beam structures with one-way ties. Method. By studying the operational features of beam structure supports, analytical and graphical dependencies between beam displacements and their support ...
A. K. Yusupov, Kh. M. Muselemov, R. I. Vishtalov   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The application of the finite element method for static behaviour analysis of the asymmetrical one-pylon suspension bridge built-in bending cables of different rigidity

Engineering Structures and Technologies, 2018
The article presents the results of the numerical analysis of the asymmetrical one-pylon suspension bridge built-in rigid cables. The models for the suspension bridge with the cables of different rigidity are analyzed by comparing vertical displacements,
Tatjana Grigorjeva, Ainars Paeglitis
doaj  

LOAD TESTING OF THE SVILAJ INTERSTATE BRIDGE

e-Zbornik. Elektronički Zbornik Radova Građevinskog Fakulteta
The paper presents static and dynamic load testing of the Svilaj interstate bridge over the Sava River. In addition to presenting the basic structural elements of the bridge, the paper briefly describes the testing method, provides the basic ...
Mladen Kustura, Marino Jurišić, Goran Šunjić   +2 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Crack-face displacements for embedded elliptic and semi-elliptical surface cracks [PDF]

Analytical expressions for the crack-face displacements of an embedded elliptic crack in infinite solid subjected to arbitrary tractions are obtained. The tractions on the crack faces are assumed to be expressed in a polynomial form.
Raju, I. S.
core   +1 more source