Results 221 to 230 of about 1,230,257 (264)

Rational Disposition Effects

SSRN Electronic Journal, 2009
The paper examines the tendency to sell winners and hold on to losers in a dynamic noisy rational expectations equilibrium with informed and uninformed investors. The key feature of the model is that the information asymmetry between investors varies over time. Besides demonstrating that the disposition effect is not intrinsically at odds with rational
Daniel Dorn, Günter Strobl
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Effects of Age on Meperidine Disposition

Survey of Anesthesiology, 1985
Elderly patients appear to be more sensitive to meperidine than younger ones; however, the contributions of altered dynamic and kinetic factors are not clear. Accordingly, seven healthy normal men aged 60 to 79 yr were simultaneously given 25 mg meperidine HCl intravenously and the same dose of deuterium-labeled drug either orally or intramuscularly ...
R. J. Herman, C B McAllister, Grant R. Wilkinson, Robert A. Branch   +3 more
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Effect of Rifampin on Theophylline Disposition

Therapeutic Drug Monitoring, 1984
The concentrations of theophylline from single 400-mg oral doses were evaluated both before and after 7 days of oral rifampin administration (600 mg/day) in six healthy, nonsmoking adults. The mean oral clearance of theophylline was significantly increased from 54.9 +/- 21.2 to 68.9 +/- 26.5 ml/h/kg.
Robert P. Henderson, Timothy H. Self, Phillip Lieberman, Arthur B. Straughn   +3 more
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Effect of cimetidine on verapamil disposition

Clinical Pharmacology and Therapeutics, 1985
The effects of multiple doses of cimetidine on single-dose verapamil kinetics were studied in nine healthy men. Baseline hepatic blood flow was estimated by indocyanine green elimination on day 1. On day 2, the subjects received verapamil, 10 mg iv, after which the plasma concentration-time profile was determined. After a 2-day washout, cimetidine, 300
Cho-Ming Loi, Michael A. Peat, Douglas E. Rollins, George E. Dukes   +3 more
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Effect of Ranitidine on Bupivacaine Disposition

Anesthesia & Analgesia, 1991
This study was undertaken to determine the effect, if any, of ranitidine on bupivacaine disposition in 28 women undergoing cesarean section. Before epidural anesthesia, ranitidine (50 mg IM) or sodium citrate (30 mL orally) was administered to groups of 14 parturients each.
Leon I. Mann, Kathy J. Zuspan, Betty R. Kuhnert, Noam Lazebnik, Wayne T. Brashear   +4 more
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Mexiletine effects on theophylline disposition

Clinical Pharmacology and Therapeutics, 1991
The effect of mexiletine administration on steady-state plasma theophylline concentrations was studied in eight normal healthy men in a prospective open label nonrandomized two-way crossover trial. Repeated doses of 300 mg of sustained-release theophylline were given every 12 hours for 9 days.
James L. Vacek, James L. Vacek, Aryeh Hurwitz, Aryeh Hurwitz, Andrew Jayaraj, Andrew Jayaraj, Gregory W. Botteron, Gregory W. Botteron, Mario I. Sztern, Mario I. Sztern, Edward M. Hughes, Edward M. Hughes   +11 more
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Effect of smoking on theophylline disposition

Clinical Pharmacology & Therapeutics, 1976
The pharmacokinetics of theophylline were examined in a group of nonsmokers and in heavy smokers (1 to 2 packs/day) before and 3 to 4 mo after cessation of cigarette smoking. The half‐life of theophylline in smokers averaged 4.3 (SD = 1.4) hr, significantly shorter than the mean value in nonsmokers (7.0, SD = 1.7 hr).
Anthony M. Yurchak, William J. Jusko, Susan N. Hunt   +2 more
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Effect of fluconazole on the disposition of phenytoin

Clinical Pharmacology and Therapeutics, 1991
In a randomized, placebo-controlled, parallel study, phenytoin was given in the presence and absence of fluconazole. Twenty healthy male subjects received phenytoin, 200 mg orally, on study days 1 to 3 and 18 to 20 and 250 mg intravenously on study days 4 and 21.
Robert A Blum, Robert A Blum, Robert A Blum, M. J. Gardner, M. J. Gardner, M. J. Gardner, John H Wilton, John H Wilton, John H Wilton, Donald M. Hilligoss, Donald M. Hilligoss, Donald M. Hilligoss, Jerome J Schentag, Jerome J Schentag, Jerome J Schentag, Nedra J. Harrison, Nedra J. Harrison, Nedra J. Harrison, Eugenia B. Henry, Eugenia B. Henry, Eugenia B. Henry   +20 more
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Effect of alcohol on propylthiouracil disposition

Clinical Pharmacology and Therapeutics, 1983
We examined the effect of ethanol on propylthiouracil (PTU) disposition in normal subjects and a rabbit. The drug is metabolized by conjugation. In six normal subjects 19.2 gm oral ethanol, taken either with or two hr after 300 mg PTU, did not change maximum concentration, time to maximum concentration, or total or free AUC of PTU.
Jake J. Thiessen, Paul Dorian, J Bennett, H. G. Giles, H Orrego, Edward M. Sellers, J P Long   +6 more
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Effect of ethanol on the disposition of paraquat

Toxicology Letters, 1991
Rabbits that received paraquat (200 mg/kg) and ethanol (1.0-3.8 g/kg) by gavage resulted in shorter median survival times and higher mortality rates than those dosed with paraquat alone. Plasma paraquat levels in rabbits dosed with ethanol before, after and concurrently with ingestion of paraquat were significantly higher when compared with animals ...
Yu Hsiu-Ying, Kuo Tsung-Li
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