Results 241 to 250 of about 9,674,565 (291)
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Effects of Age on Meperidine Disposition
Survey of Anesthesiology, 1985Elderly patients appear to be more sensitive to meperidine than younger ones; however, the contributions of altered dynamic and kinetic factors are not clear. Accordingly, seven healthy normal men aged 60 to 79 yr were simultaneously given 25 mg meperidine HCl intravenously and the same dose of deuterium-labeled drug either orally or intramuscularly ...
R J, Herman +3 more
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Determinants of Disposition and Reverse Disposition Effects
SSRN Electronic Journal, 2009We develop a new measure for disposition effects based on the average length of a trading strategy and whether it is loss-making or profitable. Using this new measure, we are able to evaluate disposition effects in more detail than has been possible previously. We find for the first time the existence of disposition and reverse disposition effects. The
Andreas Krause +2 more
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Effect of Rifampin on Theophylline Disposition
Therapeutic Drug Monitoring, 1984The concentrations of theophylline from single 400-mg oral doses were evaluated both before and after 7 days of oral rifampin administration (600 mg/day) in six healthy, nonsmoking adults. The mean oral clearance of theophylline was significantly increased from 54.9 +/- 21.2 to 68.9 +/- 26.5 ml/h/kg.
A B, Straughn +3 more
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Effect of Ranitidine on Bupivacaine Disposition
Anesthesia & Analgesia, 1991This study was undertaken to determine the effect, if any, of ranitidine on bupivacaine disposition in 28 women undergoing cesarean section. Before epidural anesthesia, ranitidine (50 mg IM) or sodium citrate (30 mL orally) was administered to groups of 14 parturients each.
W T, Brashear +4 more
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Effect of cimetidine on verapamil disposition
Clinical Pharmacology and Therapeutics, 1985The effects of multiple doses of cimetidine on single-dose verapamil kinetics were studied in nine healthy men. Baseline hepatic blood flow was estimated by indocyanine green elimination on day 1. On day 2, the subjects received verapamil, 10 mg iv, after which the plasma concentration-time profile was determined. After a 2-day washout, cimetidine, 300
C M, Loi +3 more
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Effect of phenobarbital on theophylline disposition
Journal of Allergy and Clinical Immunology, 1978The effect of chronic phenobarbital administration on the pharmacokinetics of theophylline was studied in 6 healthy, nonsmoking adults. Subject compliance was verified by the determination of plasma phenobarbital levels. Following four weeks of phenobarbital administration, all six subjects showed a resultant increase in serum clearance varying from 11%
R A, Landay, M A, Gonzalez, J C, Taylor
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Effect of Ranitidine on Chloroquine Disposition
Drug Intelligence & Clinical Pharmacy, 1987Ten healthy, male volunteers (aged 19–27 yr; weight 62–67 kg) were randomly distributed into control and test groups of five subjects each in a controlled study on the effect of ranitidine on chloroquine disposition. The control group subjects received two tablets of chloroquine sulfate (300-mg base) only.
E I, Ette, A, Brown-Awala, E E, Essien
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Effect of fluconazole on the disposition of phenytoin
Clinical Pharmacology and Therapeutics, 1991In a randomized, placebo-controlled, parallel study, phenytoin was given in the presence and absence of fluconazole. Twenty healthy male subjects received phenytoin, 200 mg orally, on study days 1 to 3 and 18 to 20 and 250 mg intravenously on study days 4 and 21.
R A, Blum +6 more
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The Effect of Probenecid on Nafcillin Disposition
The Journal of Clinical Pharmacology, 1982Abstract: Five normal male volunteers participated in an open crossover study designed to examine the disposition of nafcillin given intravenously with and without probenecid. Each subject received two 500 mg iv doses of sodium nafcillin seven days apart, one dose without probenecid and another dose during oral probenecid administration of 1.0 Gm at ...
E S, Waller +2 more
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Effect of quinolones on caffeine disposition
Clinical Pharmacology and Therapeutics, 1989Six healthy volunteers received a single caffeine dose after pretreatment with norfloxacin, pipemidic acid, or placebo in a crossover, randomized, single-blind clinical trial. Quinolones altered the pharmacokinetics of caffeine, with a significant increase in the AUCs and a decrease in plasma clearance. The elimination half-life increased significantly
M, Carbó +4 more
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