Results 251 to 260 of about 9,674,565 (291)
Some of the next articles are maybe not open access.
Aging effects on drug disposition and effect
Geriatric Nephrology and Urology, 1999Drug therapy in older individuals has generally been summarized in the phrase "start low and go slow". As better understanding of the effects and disposition of drugs in the aged has evolved, the concept of "therapeutic burden" which encompasses the number of concurrent medications as well as the dose of medications administered has assumed ...
openaire +2 more sources
Effect of pentobarbital on the disposition of alprenolol
Clinical Pharmacology & Therapeutics, 1977Alprenolol was administered orally and intravenously to 5 healthy subjects before and after IO to 14 daily doses of 0.1 gm pentobarbital. The area under the plasma concentration time curve after an oral 200‐mg dose decreased from 706 ± 277 to 154 ± 48 ng/ml .
G, Alván +3 more
openaire +2 more sources
Mexiletine effects on theophylline disposition
Clinical Pharmacology and Therapeutics, 1991The effect of mexiletine administration on steady-state plasma theophylline concentrations was studied in eight normal healthy men in a prospective open label nonrandomized two-way crossover trial. Repeated doses of 300 mg of sustained-release theophylline were given every 12 hours for 9 days.
A, Hurwitz +5 more
openaire +2 more sources
Disposition kinetics and effects of menthol
Clinical Pharmacology & Therapeutics, 1999Menthol is widely used in a variety of commercial products and foods, but its clinical pharmacology is not well studied. To determine the disposition kinetics and to examine subjective and cardiovascular effects of menthol, we conducted a crossover placebo-controlled study that compared pure menthol versus placebo, along with an uncontrolled exposure ...
Yu, L +3 more
openaire +4 more sources
Effect of smoking on theophylline disposition
Clinical Pharmacology & Therapeutics, 1976The pharmacokinetics of theophylline were examined in a group of nonsmokers and in heavy smokers (1 to 2 packs/day) before and 3 to 4 mo after cessation of cigarette smoking. The half‐life of theophylline in smokers averaged 4.3 (SD = 1.4) hr, significantly shorter than the mean value in nonsmokers (7.0, SD = 1.7 hr).
S N, Hunt, W J, Jusko, A M, Yurchak
openaire +2 more sources
Effect of ethanol on the disposition of paraquat
Toxicology Letters, 1991Rabbits that received paraquat (200 mg/kg) and ethanol (1.0-3.8 g/kg) by gavage resulted in shorter median survival times and higher mortality rates than those dosed with paraquat alone. Plasma paraquat levels in rabbits dosed with ethanol before, after and concurrently with ingestion of paraquat were significantly higher when compared with animals ...
T L, Kuo, H Y, Yu
openaire +2 more sources
Effect of alcohol on propylthiouracil disposition
Clinical Pharmacology and Therapeutics, 1983We examined the effect of ethanol on propylthiouracil (PTU) disposition in normal subjects and a rabbit. The drug is metabolized by conjugation. In six normal subjects 19.2 gm oral ethanol, taken either with or two hr after 300 mg PTU, did not change maximum concentration, time to maximum concentration, or total or free AUC of PTU.
J P, Long +6 more
openaire +2 more sources
Effect of route of administration on drug disposition
Journal of Pharmacokinetics and Biopharmaceutics, 1972An increasing body of information tends to support the hypothesis that drug effect, therapeutic or toxic, is more closely correlated with plasma concentration than dose (Levy, 1968). Absorption is one important determinant of drug plasma levels. Distribution and elimination are others.
S, Riegelman, M, Rowland
openaire +2 more sources
SSRN Electronic Journal, 2009
The paper examines the tendency to sell winners and hold on to losers in a dynamic noisy rational expectations equilibrium with informed and uninformed investors. The key feature of the model is that the information asymmetry between investors varies over time. Besides demonstrating that the disposition effect is not intrinsically at odds with rational
Daniel Dorn, Günter Strobl
openaire +1 more source
The paper examines the tendency to sell winners and hold on to losers in a dynamic noisy rational expectations equilibrium with informed and uninformed investors. The key feature of the model is that the information asymmetry between investors varies over time. Besides demonstrating that the disposition effect is not intrinsically at odds with rational
Daniel Dorn, Günter Strobl
openaire +1 more source
2012
Personalized medicine requires knowledge of factors influencing disease susceptibility and progression as well as effective treatments which minimize adverse drug reactions (ADRs). Surprisingly little attention has focused on the impact of sex on clinical therapeutics.
Amy C.M. Mattison Faye +1 more
openaire +1 more source
Personalized medicine requires knowledge of factors influencing disease susceptibility and progression as well as effective treatments which minimize adverse drug reactions (ADRs). Surprisingly little attention has focused on the impact of sex on clinical therapeutics.
Amy C.M. Mattison Faye +1 more
openaire +1 more source