Results 231 to 240 of about 15,684,009 (290)

Effect of cimetidine on verapamil disposition

Clinical Pharmacology and Therapeutics, 1985
The effects of multiple doses of cimetidine on single-dose verapamil kinetics were studied in nine healthy men. Baseline hepatic blood flow was estimated by indocyanine green elimination on day 1. On day 2, the subjects received verapamil, 10 mg iv, after which the plasma concentration-time profile was determined. After a 2-day washout, cimetidine, 300
C M, Loi, D E, Rollins, G E, Dukes, M A, Peat   +3 more
openaire   +2 more sources

Framing effect and disposition effect: investment decisions tools to understand bounded rationality

Review of Behavioral Finance
PurposeThis paper aims to explore the development of investment decision tools by understanding the rationality behind the disposition effect. We suspect that not all disposition decisions are irrational.
Andreas Kiky, A. Atahau, L. Mahastanti, S. Supatmi   +3 more
semanticscholar   +1 more source

Mexiletine effects on theophylline disposition

Clinical Pharmacology and Therapeutics, 1991
The effect of mexiletine administration on steady-state plasma theophylline concentrations was studied in eight normal healthy men in a prospective open label nonrandomized two-way crossover trial. Repeated doses of 300 mg of sustained-release theophylline were given every 12 hours for 9 days.
A, Hurwitz, J L, Vacek, G W, Botteron, M I, Sztern, E M, Hughes, A, Jayaraj   +5 more
openaire   +2 more sources

Disposition kinetics and effects of menthol

Clinical Pharmacology & Therapeutics, 1999
Menthol is widely used in a variety of commercial products and foods, but its clinical pharmacology is not well studied. To determine the disposition kinetics and to examine subjective and cardiovascular effects of menthol, we conducted a crossover placebo-controlled study that compared pure menthol versus placebo, along with an uncontrolled exposure ...
Yu, L, Benowitz, NL, Gelal, AYŞE, Jacob, P   +3 more
openaire   +4 more sources

Effect of Rifampin on Theophylline Disposition

Therapeutic Drug Monitoring, 1984
The concentrations of theophylline from single 400-mg oral doses were evaluated both before and after 7 days of oral rifampin administration (600 mg/day) in six healthy, nonsmoking adults. The mean oral clearance of theophylline was significantly increased from 54.9 +/- 21.2 to 68.9 +/- 26.5 ml/h/kg.
A B, Straughn, R P, Henderson, P L, Lieberman, T H, Self   +3 more
openaire   +2 more sources

Effect of smoking on theophylline disposition

Clinical Pharmacology & Therapeutics, 1976
The pharmacokinetics of theophylline were examined in a group of nonsmokers and in heavy smokers (1 to 2 packs/day) before and 3 to 4 mo after cessation of cigarette smoking. The half‐life of theophylline in smokers averaged 4.3 (SD = 1.4) hr, significantly shorter than the mean value in nonsmokers (7.0, SD = 1.7 hr).
S N, Hunt, W J, Jusko, A M, Yurchak
openaire   +2 more sources

Effect of fluconazole on the disposition of phenytoin

Clinical Pharmacology and Therapeutics, 1991
In a randomized, placebo-controlled, parallel study, phenytoin was given in the presence and absence of fluconazole. Twenty healthy male subjects received phenytoin, 200 mg orally, on study days 1 to 3 and 18 to 20 and 250 mg intravenously on study days 4 and 21.
R A, Blum, J H, Wilton, D M, Hilligoss, M J, Gardner, E B, Henry, N J, Harrison, J J, Schentag   +6 more
openaire   +2 more sources

Aging effects on drug disposition and effect

Geriatric Nephrology and Urology, 1999
Drug therapy in older individuals has generally been summarized in the phrase "start low and go slow". As better understanding of the effects and disposition of drugs in the aged has evolved, the concept of "therapeutic burden" which encompasses the number of concurrent medications as well as the dose of medications administered has assumed ...
openaire   +2 more sources

The Effect of Probenecid on Nafcillin Disposition

The Journal of Clinical Pharmacology, 1982
Abstract: Five normal male volunteers participated in an open crossover study designed to examine the disposition of nafcillin given intravenously with and without probenecid. Each subject received two 500 mg iv doses of sodium nafcillin seven days apart, one dose without probenecid and another dose during oral probenecid administration of 1.0 Gm at ...
E S, Waller, M A, Sharanevych, G J, Yakatan   +2 more
openaire   +2 more sources

Disposition effect in fund managers. Fund and stock-specific factors and the upshot for investors

, 2020
This paper evaluates the presence of disposition effect in Spanish equity funds and its implications for investors. We find that disposition spread is not a widespread bias, but it exists across funds.
Laura Andreu, Cristina Ortiz, J. L. Sarto   +2 more
semanticscholar   +1 more source