Results 91 to 100 of about 6,509 (259)

A real-world pharmacovigilance analysis of potential ototoxicity associated with sacubitril/valsartan based on FDA Adverse Event Reporting System (FAERS)

Scientific Reports
Sacubitril/valsartan, a first-in-class angiotensin receptor neprilysin inhibitor, is widely used to treat heart failure. Despite its efficacy, sacubitril/valsartan inevitably causes adverse events such as hypotension, renal dysfunction, hyperkalemia, and
Ning Wang, Haijun Wang, Ying Chen, Yanfeng Wang   +3 more
doaj   +1 more source

Drugs Associated with Pediatric Cataracts: A Real-World Pharmacovigilance Study

Children
Background: Pediatric cataracts are a main cause of irreversible vision loss and a significant public health challenge. This study aimed to identify pharmacovigilance signals by analyzing large-scale data from the U.S.
Jiantong Du, Chen Xing, Zhiyue Zhang, Zonghui Ma   +3 more
doaj   +1 more source

Disproportionality analysis of infection associated with antidiabetic drug use patterns

Scientific Reports
While various antidiabetic drug classes are associated with differing infection risks, comprehensive evidence on infection risk across multidrug regimens remains limited. Therefore, this study aims to investigate the pharmacovigilance signal between antidiabetic drug use and infection risk, considering the number and patterns of drug use.
Kim, Tae Hyeon, Lee, Kyeongmin, Park, Seoyoung, Park, Jaeyu, Jo, Hyesu, Lee, Hayeon, Kim, Hyunjee, Cho, Jaehyeong, Rhee, Sang Youl, Hajek, André, Branda, Francesco, Song, Tae-Jin, Kim, Jaewon, Yon, Dong Keon   +13 more
openaire   +3 more sources

Current Evidence for Circulating Tumor DNA in Sarcoma: Challenges and Opportunities for Clinical Application

Journal of Surgical Oncology, EarlyView.
ABSTRACT Sarcomas represent a diverse group of mesenchymal tumors with high rates of recurrence after resection. While recent technical advances have enabled the detection of rare circulating tumor DNA (ctDNA) in other malignancies, the complexity and heterogeneity of sarcoma genomics have historically limited ctDNA in these cancers.
Kristin E. Goodsell, Jason A. Carter, Hannah R. Abrams, Harveshp Mogal, Elizabeth T. Loggers, Jeremy Sharib   +5 more
wiley   +1 more source

Joint Risk Factor Combinations with Additive Interaction Increase the Risk of Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Combined effects of multiple risk factors on incident late‐onset Parkinson's disease (PD; LOPD) remain poorly characterized. Objective The objective of this study was to quantify the impact of joint risk exposures and estimate the contribution of potentially modifiable factors to incident LOPD risk.
Andrea Quattrone, Basilio Vescio, Fulvia Arcuri, Giuseppe Chiarella, Jolanda Buonocore, Aldo Quattrone   +5 more
wiley   +1 more source

Air pollution disproportionately impairs beneficial invertebrates: a meta-analysis

Nature Communications
AbstractAir pollution has the potential to disrupt ecologically- and economically-beneficial services provided by invertebrates, including pollination and natural pest regulation. To effectively predict and mitigate this disruption requires an understanding of how the impacts of air pollution vary between invertebrate groups.
James M. W. Ryalls, Jacob Bishop, Adedayo O. Mofikoya, Lisa M. Bromfield, Shinichi Nakagawa, Robbie D. Girling   +5 more
openaire   +4 more sources

Evaluating the Evolving Real‐World Adverse Events of GLP‐1RAs Using FDA Adverse Event Reporting System (FAERS)

Obesity, EarlyView.
Web portal for interrogating Adverse Events of GLP‐1 RA in diabetes vs weight control/obesity. ABSTRACT Objective This study aimed to assess the spectrum and frequency of adverse events (AEs) linked to glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) using the US FDA Adverse Event Reporting System (FAERS).
David Stone, Mary Playdon, Stephen D. Hursting, Aik Choon Tan   +3 more
wiley   +1 more source

Disproportionality analysis of progestogens and estrogens demonstrates increased meningioma risk

Journal of Clinical Neuroscience
This study aims to clarify the relationship between the use of various progestogens and estrogens and the risk of developing meningiomas, given the widespread prescription of hormonal contraceptives and their potential implications in tumour proliferation.Data from the FDA Adverse Event Reporting System (FAERS) was analyzed using disproportionality ...
Connor, Frey, Mahyar, Etminan
openaire   +2 more sources

Early Pregnancy Body Roundness Index and Development of Adverse Pregnancy Outcomes: A Secondary Analysis of the nuMoM2b Study

Obesity, EarlyView.
Greater body roundness index is associated with increased odds of adverse pregnancy outcomes. Thomas et al. Relationships between body roundness with body fat and visceral adipose tissue emerging from a new geometrical model. Obesity (Silver Spring). 2013 November; 21(11): 2264–2271. Central image created with BioRender.
Kelsey J. Pape, Taylor M. Bynarowicz, Sruthi Bhamidipalli, Yan Tong, Maisa N. Feghali, David M. Haas, Uma M. Reddy, Robert M. Silver, Lynn M. Yee, Christina M. Scifres   +9 more
wiley   +1 more source

Inequalities in intraspecific plant–lemur interactions drive seed dispersal patterns

Oikos, EarlyView.
Biotic interactions occur between individuals and accumulate to shape species‐level interaction structure across a community. Skewed interaction structures, where a few individuals are highly connected and most have few interactions, are increasingly identified at the individual‐level.
Jadelys Tonos, Hasinavalona Rakotoarisoa, Onja H. Razafindratsima   +2 more
wiley   +1 more source