Results 91 to 100 of about 4,594 (295)
Imagination, selves and knowledge of self: Pessoa’s dreams in The Book of Disquiet
This chapter explores insights concerning the relations among imagination, imagined selves, and knowledge of one’s own self that are to be found in Fernando Pessoa’s The Book of Disquiet.
Wiltsher, Nick, Nanay, Bence
core
The human gut microbiome across the life course
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Bernardo Soares’s remark that “anything and everything, depending on how one sees it, is a marvel or a hindrance, an all or nothing, a path or a problem” may serve to illustrate Thomas Cousineau’s critical move in his recent book An Unwritten Novel ...
Fernando Beleza
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The Fragmentary Kinetics of Writing in the Book of Disquiet
In this article we discuss the notion of literary fragment based on Fernando Pessoa’s Livro do Desassossego [Book of Disquiet], an unfinished work written between 1913 and 1935.
Manuel Portela +3 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
The relentless triumph of technology is increasingly dismissive of the human desire for interaction; we are deprived of experiences with the ordinary and become less aware of the potential such objects contain.
Hultum, Ben
core
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
This article focuses on attempts by inhabitants of the island of Samothraki, in North-Eastern Greece, to make sense of rapid soil erosion and degradation. Through the use of ethnographic vignettes, collected during my first fieldwork on the island in August of 2022, and broader ethnographic material, I show the imbrication of landscape perception with ...
openaire +3 more sources

