Results 111 to 120 of about 35,999 (288)
'All in good faith?' An ethno-historical analysis of local faith actors' involvement in the delivery of mental health interventions in northern Uganda. [PDF]
Transcult Psychiatry, 2023 Storer E, Torre C.
europepmc +1 more source
Whose land was it anyway? The Crichel Down Rules and the sale of public land [PDF]
, 2002 The guiding principle of compulsory purchase of interests in land in England and Wales is that of fairness, best stated in the words of Lord Justice Scott in Horn v Sunderland Corporation when he said that the owner has “the right to be put, so far as ...
Gibbard, Roger
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
ConfluenzeThis article proposes a linguistic-textual analysis model inspired by the construal theory of Ronald W. Langacker, with its application in a study of four Chinese translations of the preface of the Book of Disquiet, posthumous work by Fernando Pessoa ...
Yujia Zhang
doaj +1 more source
Sex Differences and Promotion Prospects in Clinical Psychology in Scotland [PDF]
, 1998 The following paper compares the gender bias in the Clinical Psychology profession in Scotland between 1990 and 1997. A larger proportion of females as compared with males are found both at the post-graduate training stage up until 1996 and at all levels
McKenzie, Karen, Murray, George
core
, 2022 The preservation of works of graphic design and their accompanying documentation is undoubtedly important, especially for a medium whose materiality is inherently ephemeral. But why is it that the graphic design archive continues to be dominated by an operative conception of the practice as a product of late-capitalist Global North industrial ...
openaire +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
A tiger by the tail: The artistry of crisis management [PDF]
, 2007 This paper explores the reasons for the failure of local and national leaders to adequately deal with the crisis that resulted from Hurricane Katrina September 2005.
Bathurst, Ralph
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source