Results 41 to 50 of about 2,396,820 (308)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Stellar dynamics and tidal disruption events in galactic nuclei

, 2012
The disruption of a star by the tidal field of a massive black hole is the final outcome of a chain of complex dynamical processes in the host galaxy. I introduce the "loss cone problem", and describe the many theoretical and numerical challenges on the ...
Alexander, Tal
core   +2 more sources

Endocrine disruption in wildlife: The future? [PDF]

, 2003
Probably the only thing that can be said with certainty about the future of this field of ecotoxicology is that predicting it is foolish; the chances of being right are very slim.
Sumpter, JP
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Supply Chain Interconnectedness in Times of Crises: A Gravity Model with DiD Analysis of COVID-19 Effects on Central and Eastern European Trade

Economies, 2023
This paper explores the impact of COVID-19-induced disruptions on supply chains, specifically focusing on the interconnectedness of supply chains and the transmission effects they cause.
Arūnas Burinskas, Viktorija Cohen, Jolanta Droždz   +2 more
doaj   +1 more source

What determines satellite galaxy disruption?

, 2010
In hierarchical structure formation, dark matter halos that merge with larger halos can persist as subhalos. These subhalos are likely hosts of visible galaxies.
Andrew R. Wetzel, Baugh, Berlind, Berrier, Bildfell, Binney, Blumenthal, Boylan-Kolchin, Boylan-Kolchin, Brainerd, Cohn, Coil, Coil, Cole, Conroy, Conroy, Conroy, Cooray, Davis, Diaferio, Diemand, Diemand, Dolag, Dubinski, Dunkley, Faltenbacher, Gao, Ghigna, Gonzalez, Gott, Hansen, Hansen, Hausman, Henriques, Jiang, Kang, Kereš, Kitzbichler, Klypin, Koester, Koester, Kravtsov, Kravtsov, Krick, Kroupa, Libeskind, Limousin, Limousin, Lin, Lin, Liu, Macciò, Maciejewski, Mandelbaum, Marchesini, Martin White, Metz, Mihos, Mo, Monaco, Moore, More, Murante, Muzzin, Nagai, Natarajan, Natarajan, Navarro, Ostriker, Padmanabhan, Peacock, Peñarrubia, Purcell, Reichardt, Rudick, Saro, Seljak, Shankar, Sheldon, Simha, Skibba, Smoot, Sommer-Larsen, Springel, Stewart, Tasitsiomi, Taylor, Tegmark, Tinker, Tormen, Vale, Van Den Bosch, Van Den Bosch, Van Den Bosch, Wang, Wang, Weinberg, Weinmann, Wetzel, Wetzel, White, White, White, White, Willman, Yang, Yang, Yang, Yang, Zehavi, Zentner, Zheng, Zibetti   +112 more
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Quantitative Description of Digital Media

Journal of Quantitative Description: Digital Media, 2021
We introduce the rationale for a new peer-reviewed scholarly journal, the Journal of Quantitative Description: Digital Media. The journal is intended to create a new venue for research on digital media and address several deficiencies in the current ...
Kevin Munger, Andrew M. Guess, Eszter Hargittai   +2 more
doaj   +1 more source

Modelling the light-curves of objects tidally disrupted by a black hole

, 2009
Tidal disruption by massive black holes is a phenomenon, during which a large part of gravitational energy can be released on a very short time-scale. The time-scales and energies involved during X-ray and IR flares observed in Galactic centre suggest ...
A. Gomboc, A. Čadež, Carter, Carter, Gomboc, Laguna, Luminet, M. Calvani, U. Kostić, Čadež, Čadež, Calvani   +10 more
core   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source