Results 61 to 70 of about 401,655 (316)

Globally disruptive events show predictable timing patterns [PDF]

International Journal of Astrobiology, 2016
AbstractGlobally disruptive events include asteroid/comet impacts, large igneous provinces and glaciations, all of which have been considered as contributors to mass extinctions. Understanding the overall relationship between the timings of the largest extinctions and their potential proximal causes remains one of science's great unsolved mysteries ...
Michael Gillman, Hilary E. Erenler
openaire   +2 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Cross-tokamak disruption prediction based on domain adaptation

Nuclear Fusion
The high acquisition cost and the significant demand for disruptive discharges for data-driven disruption prediction models in future tokamaks pose an inherent contradiction in disruption prediction research.
Chengshuo Shen, Wei Zheng, Bihao Guo, Yonghua Ding, Dalong Chen, Xinkun Ai, Fengming Xue, Yu Zhong, Nengchao Wang, Biao Shen, Binjia Xiao, Zhongyong Chen, Yuan Pan, J-TEXT Team   +13 more
doaj   +1 more source

Black-Hole Spin Dependence in the Light Curves of Tidal Disruption Events

, 2012
A star orbiting a supermassive black hole can be tidally disrupted if the black hole's gravitational tidal field exceeds the star's self gravity at pericenter.
A. C. Fabian, A. M. Beloborodov, A. Z. Petrov, A. Z. Petrov, B. Carter, E. S. Phinney, F. Hoyle, G. Lodato, J. Lense, J.-P. Luminet, Michael Kesden, N. Bade, P. W. Guilbert, R. Moderski, R. D. Blandford, R. M. Wald, S. Komossa, S. L. Shapiro   +17 more
core   +1 more source

Life events and hemodynamic stress reactivity in the middle-aged and elderly [PDF]

, 2005
Recent versions of the reactivity hypothesis, which consider it to be the product of stress exposure and exaggerated haemodynamic reactions to stress that confers cardiovascular disease risk, assume that reactivity is independent of the experience of ...
Aiken L. S., Allen M. T., Benschop R. J., Boyce W. T., Brown G. W., Cacioppo J. T., Carroll D., Carroll D., Carroll D., Everson S. A., Eysenck H. J., Lepore S. J., Light K. C., Linden W., Lynch J. W., Manuck S. B., Markovitz J. H., Matthews K. A., Matthews K. A., Musante L., Phillips A. C., Pike J. L., Registrar General, Treiber F. A., Treiber F. A., West S. G.   +25 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Dancing to ChaNGa: A Self-Consistent Prediction For Close SMBH Pair Formation Timescales Following Galaxy Mergers [PDF]

, 2018
We present the first self-consistent prediction for the distribution of formation timescales for close Supermassive Black Hole (SMBH) pairs following galaxy mergers.
Governato, Fabio, Pontzen, Andrew, Quinn, Thomas R., Tremmel, Michael, Volonteri, Marta   +4 more
core   +3 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Vi-DP: low-latency video-based disruption prediction with multi-FOV fusion in EAST

Nuclear Fusion
Plasma disruption poses a significant safety challenge for future tokamaks and fusion reactors. Prior work on disruption prediction relies primarily on multiple scalar zero-dimensional (0D) signals and one-dimensional (1D) profiles as input of the ...
M.W. Chen, K.J. Yang, J.J. Zhu, Q.J. Wang, F. Cheng, D.L. Chen, X.Z. Gong, B. Zhang, X.H. Zhang, Y.M. Duan, B.F. Gao, Y. Wang, W. Wang, Z.F. Guan, R.Z. Chen   +14 more
doaj   +1 more source

Sleep, circadian system and traumatic stress

European Journal of Psychotraumatology, 2021
The human circadian system creates and maintains cellular and systemic rhythmicity essential for the temporal organization of physiological processes promoting homeostasis and environmental adaptation.
Agorastos Agorastos, Miranda Olff
doaj   +1 more source