Results 131 to 140 of about 889,606 (319)

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

MOESM1 of Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential

, 2019
Additional file 1.
Thümmler, Katja, Rom, Eran, Zeis, Thomas, Lindner, Maren, Brunner, Sarah, Cole, John, Arseni, Diana, Mücklisch, Steve, Edgar, Julia, Schaeren-Wiemers, Nicole, Yayon, Avner, Linington, Christopher   +11 more
openaire   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

MOESM4 of Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential

, 2019
Additional file 4. Online Resource 4: Full list of enriched GO terms for genes more up-regulated by FGF2.
Thümmler, Katja, Rom, Eran, Zeis, Thomas, Lindner, Maren, Brunner, Sarah, Cole, John, Arseni, Diana, Mücklisch, Steve, Edgar, Julia, Schaeren-Wiemers, Nicole, Yayon, Avner, Linington, Christopher   +11 more
openaire   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Pericyte–fibroblast transition promotes tumor growth and metastasis

Proceedings of the National Academy of Sciences of the United States of America, 2016
K. Hosaka, Yunlong Yang, T. Seki, Carina Fischer, O. Dubey, E. Fredlund, J. Hartman, P. Religa, Hiromasa Morikawa, Y. Ishii, M. Sasahara, O. Larsson, G. Cossu, R. Cao, Sharon Lim, Yihai Cao   +15 more
semanticscholar   +1 more source

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. [PDF]

, 2016
In this study, because excessive polycythemia is a predominant trait in some high-altitude dwellers (chronic mountain sickness [CMS] or Monge's disease) but not others living at the same altitude in the Andes, we took advantage of this human experiment ...
Appenzeller, Otto, Azad, Priti, Bafna, Vineet, Cabrales, Pedro J, Haddad, Gabriel G, Hsiao, Yu Hsin, Poulsen, Orit, Ronen, Roy, Zhao, Huiwen W, Zhou, Dan   +9 more
core  

MOESM2 of Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential

, 2019
Additional file 2. Online Resource 2: N-terminal deletion of FGF2 results in selective activation of FGFR1.
Thümmler, Katja, Rom, Eran, Zeis, Thomas, Lindner, Maren, Brunner, Sarah, Cole, John, Arseni, Diana, Mücklisch, Steve, Edgar, Julia, Schaeren-Wiemers, Nicole, Yayon, Avner, Linington, Christopher   +11 more
openaire   +1 more source

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

MOESM5 of Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential

, 2019
Additional file 5. Online Resource 5: Pathways of genes differentially regulated in FGF2 vs F2 V2.
Thümmler, Katja, Rom, Eran, Zeis, Thomas, Lindner, Maren, Brunner, Sarah, Cole, John, Arseni, Diana, Mücklisch, Steve, Edgar, Julia, Schaeren-Wiemers, Nicole, Yayon, Avner, Linington, Christopher   +11 more
openaire   +1 more source