Results 111 to 120 of about 33,942 (277)

Immunocytochemical analysis of chromaffin cell proliferation in vitro.

, 1992
The bromodeoxyuridine (BrdU) incorporation technique for immunocytochemical labeling of S-phase nuclei was optimized for the study of chromaffin cell proliferation.
A S Tischler, L A Ruzicka, J C Riseberg
core   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Outline for the differentiation of mouse embryonic stem cells (mESCs) into motor neurons (MNs).

, 2014
mESCs were first converted into neuron-primed embryoid bodies (EBs) by treatment with noggin, fibroblast growth factor 2 (FGF2) and FGF8b for 2 days. The neuron-primed EBs were then directed to differentiate into MN spheres by treatment with retinoic ...
Ashlee W. Harris (626361), Brewster F. Kingham (626362), Lynn M. Opdenaker (626364), Suzanne M. McCahan (626365), Wenlan Wang (363252), Matthew E. R. Butchbach (34599), Miho Maeda (78967), Casey J. Lumpkin (626363)   +7 more
core   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Characterisation of a laminarin sulphate which inhibits basic fibroblast growth factor binding and endothelial cell proliferation

, 1995
We have evaluated a series of laminarin sulphates with different degrees of sulphation (0.3-2.3) as antagonists of basic fibroblast growth factor (bFGF) and as inhibitors of the bFGF-dependent endothelial cell line FBHE.
Hoffmann, R., Alban, S., Franz, Gerhard, Donaldson, J., Paper, D. H.   +4 more
core  

Nerve growth factor stimulates neurite regeneration but not survival of adult auditory neurons in vitro.

, 1992
peer reviewedInjury to either the peripheral or central nervous system results in the accumulation of growth factors at the wound site. Some of these growth factors have been shown to participate in the neural repair process. Adult auditory neurons grown
Weber, T., Lefebvre, Philippe P, Staecker, Hinrich, Staecker, H., Ruben, Robert J, Galinovic-Schwartz, V., Moonen, Gustave, Weber, Thierry, Van de Water, T. R., Galinović-Schwartz, Vera, Van De Water, Thomas R, Lefèbvre, Philippe, Ruben, R. J.   +12 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Embryonic cerebral cortex cells retain CNS phenotypes after transplantation into peripheral nerve

, 2004
Differentiation of stem cells depends on environmental cues. In this study, acutely dissociated or expanded cells derived from embryonic day 14 (E14) rat cerebral cortex were transplanted into the distal tibial nerve stump of adult Fischer rats to ...
Gajavelli, Shyam, Grumbles, Robert M, Byer, David, Tsoulfas, Pantelis, Thomas, Christine K, Aparicio, Beatriz, Baez, Juan Carlos   +6 more
core   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Stabilization of basic fibroblast growth factor with dextran sulfate

, 1992
Dextran sulfate protected bFGF from heat and acid inactivation and from proteolytic degradation. The protective effect was stronger than that of heparin which is known as a stabilizer of bFGF.
Kawahara, Kenji, Kenji Kawahara, Tomoko Kajio, Koichi Kato, Kajio, Tomoko, Kato, Koichi   +5 more
core   +1 more source