Results 91 to 100 of about 33,942 (277)

The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner

open access: yes
The glucocorticoid receptor (GR) mediates many activating and repressive effects of glucocorticoids in multiple contexts. Glucocorticoids can robustly induce the transcriptionally active protein Zinc finger and BTB domain containing 16 (ZBTB16).
Schlingemann, R.O.   +10 more
core   +1 more source

Multilayered Digital Microfluidic Chip for Cell‐Based Assays

open access: yesAdvanced Materials Interfaces, EarlyView.
A multilayered digital microfluidic (mDMF) chip architecture is introduced to improve throughput and robustness in cell‐based assays. By multilayering electrode components and dielectric layers on glass, this design significantly reduces actuation voltage, maintains reliability, and enables expansion of the operational area with minimum current leakage.
Mert Ozden   +2 more
wiley   +1 more source

Induced in Vitro Differentiation of β-Tubulin III Expressed Cells from Human Amniotic Epithelial Cells

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2012
<p><strong><em>Background and Objectives</em></strong>: The differentiation of neural cells from embryonic stem cells is influenced by several factors.
H Niknejad
doaj  

Denovo Generation of Neuronal Cells From the Adult-Mouse Brain

open access: yes, 1992
Cells of neuronal morphology, expressing the 150- and 200-kDa neurofilament proteins, were generated in vitro from populations of neural cells dissociated from adult (>60-day-old) mouse brain.
Richards, LJ   +2 more
core   +1 more source

Additive‐Manufactured, Multifunctional Bioreactor Technology for Dynamic Culture of 3D Bioprinted Tissue Models

open access: yesAdvanced Materials Technologies, EarlyView.
We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger   +9 more
wiley   +1 more source

Schematic overview of the in vitro scarring model.

open access: yes, 2015
Droplets of cortical astrocytes (A) and meningeal fibroblasts (F) were plated and allowed to grow in monolayers that contacted each other between 7 and 14 days. Then, TGF-β1 was added and incubated for 7 d. During this period, clusters were formed by the
Stefanie Krafft (776859)   +7 more
core   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

open access: yesAdvanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang   +13 more
wiley   +1 more source

Insight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study

open access: yesDrug Design, Development and Therapy, 2017
Donglou Liang,1,* Qiaowan Chen,2,* Yujin Guo,1 Ting Zhang,3 Wentao Guo4 1Pharmacy Department, Jining First People’s Hospital, 2Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 3Department of ...
Liang D, Chen Q, Guo Y, Zhang T, Guo W
doaj  

Derivation of E-RoSH cell lines.

open access: yes, 2013
(a) ESCs were plated singly on methycellulose based media to form EBs. At day 3–6, EBs were harvested, dissociated by collagenase and cultured as a monolayer on gelatinized feeder plate.
Jianwen Que (66893)   +8 more
core   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

open access: yesAdvanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia   +17 more
wiley   +1 more source

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