Results 61 to 70 of about 1,577,920 (354)

The formation of supermassive black holes in the first galaxies

, 2010
We discuss the formation of supermassive black holes in the early universe, and how to probe their subsequent evolution with the upcoming mm/sub-mm telescope ALMA.
Banerjee, Robi, Glover, Simon C. O., Klessen, Ralf S., Schleicher, Dominik R. G., Spaans, Marco, Sur, Sharanya   +5 more
core   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Mechanism of DNA Recognition at a Viral Replication Origin [PDF]

, 2006
Recognition of the DNA origin by the Epstein-Barr nuclear antigen 1 (EBNA1) protein is the primary event in latentphase genome replication of the Epstein-Barr virus, a model for replication initiation in eukaryotes.
de Prat Gay, Gonzalo, Frappier, Lori, Freire Espeleta, Eleonora, Oddo, Cristian   +3 more
core   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Latest News: Reactions of Group 4 Bis(trimethylsilyl)acetylene Metallocene Complexes and Applications of the Obtained Products

ChemistryOpen, 2021
Recently published reactions of group 4 metallocene bis(trimethylsilyl)acetylene (btmsa) complexes from the last two years are reviewed. Complexes like Cp’2Ti(η2‐Me3SiC2SiMe3) and Cp2Zr(py)(η2‐Me3SiC2SiMe3) with Cp’ as Cp (cyclopentadienyl) and Cp ...
Prof. Uwe Rosenthal
doaj   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry.

Proceedings of the National Academy of Sciences of the United States of America, 2004
Peptide sequence analysis using a combination of gas-phase ion/ion chemistry and tandem mass spectrometry (MS/MS) is demonstrated. Singly charged anthracene anions transfer an electron to multiply protonated peptides in a radio frequency quadrupole ...
J. Syka, J. Coon, M. Schroeder, J. Shabanowitz, D. Hunt   +4 more
semanticscholar   +1 more source

Modelling Primordial Gas in Numerical Cosmology [PDF]

, 1996
We have reviewed the chemistry and cooling behaviour of low-density (n H2 + H+, and H- + H -> H2 + e-, is likely to be converted into its para configuration on a faster time scale than the formation time scale.
Abel, Aldrovandi, Allison, Allison, Anninos, Anninos, Bell, Bieniek, Black, Browne, Cen, Corrigan, Couchman, Couchman, Dalgarno, Dalgarno, De Jong, Dolder, Donahue, Dove, Dove, Dove, Dunn, Ferland, Flower, Haiman, Hollenbach, Hummer, Hutchins, Janev, Janev, Karpas, Kashlinsky, Latter, Launay, Lennon, Lenzuni, Lepp, Lepp, Mac Low, Mandy, Martin, Martin, Michael L. Norman, Mihalas, Mitchell, Moessner, Moseley, Nakashima, O'Neil, Osterbrock, Osterbrock, Padoan, Palla, Peart, Peebles, Peebles, Peter Anninos, Poulaert, Prasad, Puy, Ramaker, Rawlings, Rees, Sargent, Saslaw, Sauval, Schneider, Senekowitsch, Shapiro, Shull, Shull, Sobelman, Stahler, Stancil, Stancil, Stecher, Sun, Szucs, Szucs, Tegmark, Tom Abel, Vietri, Wadehra, Wishart, Yu Zhang   +85 more
core   +2 more sources

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Novel Mechanism-Based Descriptors for Extreme Ultraviolet-Induced Photoacid Generation: Key Factors Affecting Extreme Ultraviolet Sensitivity

Molecules, 2023
Predicting photolithography performance in silico for a given materials combination is essential for developing better patterning processes. However, it is still an extremely daunting task because of the entangled chemistry with multiple reactions among ...
Ji Young Park, Hyun-Ji Song, Thanh Cuong Nguyen, Won-Joon Son, Daekeon Kim, Giyoung Song, Suk-Koo Hong, Heeyoung Go, Changmin Park, Inkook Jang, Dae Sin Kim   +10 more
doaj   +1 more source