Results 81 to 90 of about 1,352,916 (332)

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

X-ray Photospectroscopy and Electronic Studies of Reactor Parameters on Photocatalytic Hydrogenation of Carbon Dioxide by Defect-Laden Indium Oxide Hydroxide Nanorods

Molecules, 2019
In the study reported herein, glovebox-protected X-ray photoelectron spectroscopy (XPS) and in situ Hall charge carrier measurements provide new insights into the surface physical chemistry of gaseous H2, CO2, and H2+CO2 combined with nanostructured In2O(
Joel Y. Y. Loh, Nazir P. Kherani
doaj   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Detection of interstellar SO(+) - A diagnostic of dissociative shock chemistry

The Astrophysical Journal, 1992
SO + , predicted to form efficiently by dissociative shocks (Neufeld & Dalgarno, 1989, ApJ, 340), has been detected in the shocked molecular clump IC 443G, by means of four transitions at 3 and 1.3 mm wavelength. Its large line width establishes its formation by shocks, and the physical conditions derived from statistical equilibrium calculations match
openaire   +2 more sources

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

A quimiometria nos cursos de graduação em química: proposta do uso da análise multivariada na determinação de pkª

Química Nova, 2014
An experiment was proposed applying the Chemometric approach of Multivariate Analysis for inclusion in undergraduate Chemistry courses to promote and expand the use of this analytical-statistical tool. The experiment entails the determination of the acid
Paulo Cesar de Souza Pereira, Camila Fabiano de Freitas, Cristiane Santi Chaves, Bianca Martins Estevão, Diogo Silva Pellosi, André Luiz Tessaro, Vagner Roberto Batistela, Ieda Spacino Scarminio, Wilker Caetano, Noboru Hioka   +9 more
doaj   +1 more source

A quantum chemistry study of the dissociation and isomerization reactions of methylene amidogene

Journal of Molecular Structure: THEOCHEM, 2007
Abstract Quantum chemistry calculations at the MP2 and MRCI levels have been used to compute the energies of the stationary points and the minimum energy pathways (MEPs) between them for the dissociation and isomerization reactions of the methylene amido-gene radical. The MEPs for H2CN → trans-HCNH → cis-HCNH, H2CN → H + HCN, cis-HCNH → H + {HCN, HNC}
Metropoulos, Aristophanes, Thompson, D. L.   +1 more
openaire   +2 more sources

On the Theory of Electrolytic Dissociation, the Greenhouse Effect, and Activation Energy in (Electro)Catalysis: A Tribute to Svante Augustus Arrhenius.

Chemistry, 2019
Svante Augustus Arrhenius (1859, Vik - 1927, Stockholm) received the Nobel Prize for Chemistry in 1903 "in recognition of the extraordinary services he rendered to the advancement of chemistry by his electrolytic theory of dissociation".
Justus Masa, Stefan Barwe, C. Andronescu, W. Schuhmann   +3 more
semanticscholar   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source