Results 81 to 90 of about 380,728 (341)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

De Svante Arrhenius ao peagâmetro digital: 100 anos de medida de acidez From Svante Arrhenius to the digital ph meter: a century of acidity measurement

Química Nova, 2007
This work describes the establishment of the concept of pH and the evolution of its measurement. The origin of the pH definition can be found in the development of the chemistry of aqueous solutions during the XIXth century. The electrolytic dissociation
Michelle da Silva Gama, Júlio Carlos Afonso   +1 more
doaj   +1 more source

On the Energy-specific Photodissociation Pathways of 14N2 and 14N15N Isotopomers to N Atoms of Different Reactivity: A Quantum Dynamical Perspective

The Astrophysical Journal, 2023
Photodissociation of the nitrogen molecule in the vacuum ultraviolet (VUV) is a major source of reactive nitrogen atoms in the upper atmosphere of Earth and throughout the solar system.
Natalia Gelfand, Ksenia Komarova, Francoise Remacle, Raphael D. Levine   +3 more
doaj   +1 more source

A computational study of CS bond dissociation enthalpies in petroleum chemistry [PDF]

Heteroatom Chemistry, 2010
AbstractHigh‐level theoretical methods (BMK, B3LYP, B98, B3P86, B3PW91, PBE1PBE, PBE1KIS, MPWPW91, MPW1KCIS, TPSS1KCIS, G3, G3//BMK, and CBS‐Q) were utilized to study the carbon–sulfur bond dissociation enthalpies (BDEs) of hydrocarbons in petroleum chemistry.
Xi-Rui Hu, Jing Shi, Shuang Liang
openaire   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Sensing Microorganisms Using Rapid Detection Methods: Supramolecular Approaches

Biosensors
Supramolecular chemistry relies on the dynamic association/dissociation of molecules through non-covalent interactions. These interactions of a self-assembled system can be strategically exploited for sensing several microorganisms.
Hiya Lahiri, Kingshuk Basu
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Galaxy QCxMS for straightforward semi-empirical quantum mechanical EI-MS prediction

GigaByte
High-performance computing (HPC) environments are crucial for computational research, including quantum chemistry (QC), but pose challenges for non-expert users.
Wudmir Y. Rojas , Zargham Ahmad , Julia Jakiela , Helge Hecht , Jana Klánová , Elliott J. Price   +5 more
doaj   +1 more source

Hydrodynamical simulations of the decay of high-speed molecular turbulence. I. Dense molecular regions

, 2002
We present the results from three dimensional hydrodynamical simulations of decaying high-speed turbulence in dense molecular clouds. We compare our results, which include a detailed cooling function, molecular hydrogen chemistry and a limited C and O ...
Alexander Rosen, Ballesteros-Paredes, Balsara, Blitz, Burkert, Davis, Georgi Pavlovski, Hartmann, Heitsch, Herbst, Hollenbach, Hollenbach, Katz, Klessen, Langer, Lepp, Lim, Lim, Mac Low, Mac Low, Mac Low, McKee, Michael D. Smith, Mordecai-Mark Mac Low, Neufeld, Padoan, Padoan, Passot, Smith, Smith, Smith, Stone, Stone, Stone, Sutherland, Suttner, Vázquez-Semadeni, Vázquez-Semadeni, Vázquez-Semadeni, Williams   +39 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source