Results 61 to 70 of about 463,636 (339)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Kinetic and Structural Analysis of the Mg2+ -binding Site of the Guanine Nucleotide-binding Protein p21 H-ras. [PDF]

, 1993
The coordination and binding of the Mg2+ ion in the nucleotide−binding site of p21 have been investigated using site−directed mutagenesis, kinetic methods, and phosphorous NMR.
Borasio, Gian Domenico, Goody, R. S., John, J., Rensland, H., Schlichting, I., Vetter, I., Wittinghofer, A.   +6 more
core  

The theoretical study on interaction of hydrogen with single-walled boron nitride nanotubes. I. The reactive force field ReaxFFHBN development [PDF]

, 2005
We present a new reactive force field ReaxFFHBN derived to accurately model large molecular and condensed phase systems of H, B, and N atoms. ReaxFFHBN has been tested against quantum calculation data for B–H, B–B, and B–N bond dissociations and for H–B ...
Goddard, William A., III, Han, Sang Soo, Kang, Jeung Ku, Lee, Hyuck Mo, van Duin, Adri C. T.   +4 more
core   +1 more source

Certification and shelf-life extension of a new batch of the branch reference standard for live tularemic vaccine's specific activity and immunogenicity

Биопрепараты: Профилактика, диагностика, лечение, 2018
The article presents the results obtained in the study of a new batch of a candidate branch reference standard for live tularemic vaccine (vaccine BRS). The candidate vaccine BRS was represented by a commercial batch of a product that met all applicable ...
I. V. Kasina, A. A. Goryaev, L. I. Rashchepkin, O. V. Fadeykina, T. I. Nemirovskaya, O. B. Ustinnikova, O. A. Lobovikova, S. A. Alekseeva, R. A. Volkova, A. A. Movsesyants   +9 more
doaj  

Spontaneous dissociation of Co2(CO)8 and autocatalytic growth of Co on SiO2: A combined experimental and theoretical investigation

Beilstein Journal of Nanotechnology, 2012
We present experimental results and theoretical simulations of the adsorption behavior of the metal–organic precursor Co2(CO)8 on SiO2 surfaces after application of two different pretreatment steps, namely by air plasma cleaning or a focused electron ...
Kaliappan Muthukumar, Harald O. Jeschke, Roser Valentí, Evgeniya Begun, Johannes Schwenk, Fabrizio Porrati, Michael Huth   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Atomic structure of dislocation kinks in silicon

, 1997
We investigate the physics of the core reconstruction and associated structural excitations (reconstruction defects and kinks) of dislocations in silicon, using a linear-scaling density-matrix technique.
B. Ya. Farber, B. Ya. Farber, David Vanderbilt, F. H. Stillinger, G. A. Baraff, G.-X. Qian, H. Alexander, H. Gottschalk, H. R. Kolar, H. Teichler, I. Kwon, J. Bennetto, J. Bennetto, J. E. Northrup, J. P. Hirth, J. R. Chelikowsky, J. R. Chelikowsky, J. R. K. Bigger, K. Maeda, L. B. Hansen, M. I. Heggie, M. I. Heggie, M. I. Heggie, M. I. Heggie, M. S. Duesbery, P. B. Hirsch, P. N. Keating, R. Jones, R. Jones, R. W. Nunes, R. W. Nunes, S. Marklund, S. Marklund, S. Öberg, T. A. Arias, V. Celli, V. I. Nikitenko, V. Rubin, V. V. Bulatov, X.-P. Li, Y. M. Huang   +40 more
core   +1 more source

Intentional Action in Folk Psychology: An Experimental Investigation [PDF]

, 2003
Four experiments examined people’s folk-psychological concept of intentional action. The chief question was whether or not evaluative considerations — considerations of good and bad, right and wrong, praise and blame — played any role in that concept ...
Knobe, Joshua
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Impact of acidity and surface-modulated acid dissociation on cloud response to organic aerosol [PDF]

Atmospheric Chemistry and Physics
Acid dissociation of the organic aerosol fraction has the potential to impact cloud-activating properties by altering aqueous-phase H+ concentrations and water activity but is currently overlooked in most atmospheric aerosol models.
G. Sengupta, M. Zheng, M. Zheng, N. L. Prisle   +3 more
doaj   +1 more source