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Behavioural Brain Research, 2020
Ketamine induces safe and effective anesthesia and displays unusual cataleptic properties that gave rise to the term dissociative anesthesia. Since 1970, clinicians only utilized the drug as an anesthetic or analgesic for decades, but ketamine was found to have rapid acting antidepressant effects in 1990s. Accumulated evidence exhibits NMDAR antagonism
Eli, Lavender +2 more
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Ketamine induces safe and effective anesthesia and displays unusual cataleptic properties that gave rise to the term dissociative anesthesia. Since 1970, clinicians only utilized the drug as an anesthetic or analgesic for decades, but ketamine was found to have rapid acting antidepressant effects in 1990s. Accumulated evidence exhibits NMDAR antagonism
Eli, Lavender +2 more
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European Journal of Pharmacology, 1995
The effects of local anesthetics on amino acid-induced currents were examined using the whole-cell configuration of the patch clamp technique in dissociated hippocampal pyramidal neurons of the rat. Lidocaine (3 mM) decreased the glycine-induced Cl- current (Gly-ICl) more potently (to 46% of the control value) than the gamma-aminobutyric acid-induced ...
M, Hara, Y, Kai, Y, Ikemoto
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The effects of local anesthetics on amino acid-induced currents were examined using the whole-cell configuration of the patch clamp technique in dissociated hippocampal pyramidal neurons of the rat. Lidocaine (3 mM) decreased the glycine-induced Cl- current (Gly-ICl) more potently (to 46% of the control value) than the gamma-aminobutyric acid-induced ...
M, Hara, Y, Kai, Y, Ikemoto
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Psychopharmacology, 1991
A simple and rapid method for detecting the behavioral effects of phencyclidine and related dissociative anesthetics is described. Dissociative anesthetics such as phencyclidine (PCP) and dizolcipine, which bind with high affinities at N-methyl-D-aspartate (NMDA) coupled cation channels ("PCP receptors"), produced a dose-related increase in the ...
G E, Evoniuk, R P, Hertzman, P, Skolnick
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A simple and rapid method for detecting the behavioral effects of phencyclidine and related dissociative anesthetics is described. Dissociative anesthetics such as phencyclidine (PCP) and dizolcipine, which bind with high affinities at N-methyl-D-aspartate (NMDA) coupled cation channels ("PCP receptors"), produced a dose-related increase in the ...
G E, Evoniuk, R P, Hertzman, P, Skolnick
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"Crime scene investigation" at an anesthetic cocktail party with atrioventricular dissociation.
Middle East journal of anaesthesiology, 2012A healthy 21-year-old female patient received midazolam, propofol, fentanyl, rocuronium, nitrous oxide in oxygen, ranitidine, diclofenac, neostigmine and glycopyrrolate during the anesthetic process for elective knee arthroscopy and developed a complete AV dissociation with a P-wave frequency of 40 and a "small" QRS-complex frequency of 55 beats/min ...
Christoph J, Schlimp +1 more
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Alpha-2 agonist dissociative anesthetic combinations in fallow deer (Cervus dama).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2000Three anesthetic protocols, each using an alpha-2 agonist sedative in combination with a dissociative anesthetic, were evaluated in 17 captive fallow deer (Cervus dama). The alpha-2 agonist was given first in two of the three protocols: 1) detomidine (0.1-0.2 mg/kg i.m.) followed by tiletamine-zolazepam (3.0-6.3 mg/kg i.m.) and 2) xylazine (0.6-0.9 mg ...
M E, Galka +4 more
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Ketamine HCl, a dissociative anesthetic for squirrel monkeys (Saimiri sciureus).
Laboratory animal science, 1976A series of 3 experiments performed in squirrel monkeys showed that ketamine HCl was satisfactory for chemical restraint at doses of less than 13 mg/kg. Doses of 25 mg/kg and above produced surgical anesthesia. When serial doses of ketamine HCl were given to squirrel monkeys at regular intervals, predictable anesthesia and recovery times were produced.
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Patient Acceptance of Dissociative Anesthetics
Survey of Anesthesiology, 1984B. L. CUNNINGHAM +2 more
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Dissociation Constants of Local Anesthetics and Their Temperature Dependence
Anesthesia & Analgesia, 1983H, Kamaya, J J, Hayes, I, Ueda
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CORTICAL MECHANISMS OF DISSOCIATIVE ANESTHETICS
Anesthesiology, 1992A. D. Weissman, A. Stanec
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