Results 51 to 60 of about 21,874 (269)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Validity and reliability of the Structured Clinical Interview for Depersonalization-Derealization Spectrum (SCI-DER). [PDF]
, 2008 This study evaluates the validity and reliability of a new instrument developed to assess symptoms of depresonalization: the Structured Clinical Interview for the Depersonalization-Derealization Spectrum (SCI-DER).
Calugi, S +8 more
core +2 more sources
FOUR SELVES OF A STUDENT – A CASE REPORT OF DISSOCIATIVE IDENTITY DISORDER [PDF]
Psychiatria Fennica, 2021 Dissociative identity disorder’s origin is often traced back to early traumatization. This disorder is difficult to diagnose within a short appointment, and the patient may appear psychotic.
Henna Haravuori, MD, PhD +4 more
doaj
A REVIEW ON DISSOCIATIVE IDENTITY DISORDER
Asian Journal of Hospital Pharmacy, 2020 A brief description of factors related to diagnosis and treatment is presented with epidemiology, risk factors, socio-cultural aspects of dissociative identity disorder which was previously known as multiple personality disorder. It highlights the points on the current research and particular recommendations which should also be done in the future ...
Sudha Thooloori +5 more
openaire +1 more source
Dissociative Identity Disorder: An In-Depth Look [PDF]
, 2018 Dissociative Identity Disorder is a mental health disorder where there are two or more distinct people within one individual. These distinct people or personalities are also called alters.
Horchner, Brittany
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source