Results 101 to 110 of about 525,078 (332)

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Ternary Solid Dispersions as an Alternative Approach to Enhance Pharmacological Activity

open access: yesDrug Design, Development and Therapy
Salma Amaliah,1 Diah Lia Aulifa,2 Amirah Mohd Gazzali,3 Arif Budiman1 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Department of Pharmaceutical Analysis and ...
Amaliah S   +3 more
doaj  

Avaliação da capacidade de dissolução de tecido pulpar bovino pelo hipoclorito de sódio em diferentes concentrações

open access: yesRevista de Odontologia da UNESP
ResumoIntroduçãoO hipoclorito de sódio é a substância química auxiliar do tratamento endodôntico mais utilizada devido à sua ação antimicrobiana e à sua capacidade de dissolver matéria orgânica.ObjetivoO objetivo do presente estudo foi comparar a ...
Adriane Wendling PITOME   +4 more
doaj   +1 more source

Application of Cold Metal Transfer Welding for High Pressure Die Casting Mold Restoration

open access: yesMetals, 2019
This paper presents results of the research focused on the possibility of the restoration of the shape parts of molds made of X15CrNiSi20-12 (EN 100 95) heat-resistant austenitic chromium-nickel stainless steel working in high-pressure die casting of ...
Janette Brezinová   +7 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

EFAVIRENZ MICROCRYSTALS FOR DISSOLUTION ENHANCEMENT - FLUID-BED GRANULATION, SCALE UP, TABLETING AND PHARMACOKINETICS [PDF]

open access: yesQuímica Nova
Efavirenz, an antiretroviral drug, is a class 2 according to the biopharmaceutics classification system. Many dissolution enhancement systems have been tried and our group had success using wet milling to decrease particle size and granules were obtained
Livia Deris Prado   +5 more
doaj   +1 more source

Molecular and genetic mechanisms conferring dissolution of dioecy in Diospyros oleifera Cheng [PDF]

open access: gold, 2022
Peng Sun   +14 more
openalex   +1 more source

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