Results 71 to 80 of about 1,185,001 (388)

Dexibuprofen nanocrystals with improved therapeutic performance: fabrication, characterization, in silico modeling, and in vivo evaluation

International Journal of Nanomedicine, 2018
Naseem Ullah,1 Shahzeb Khan,1 Shaimaa Ahmed,2 Thirumala Govender,2 Hani S Faidah,3 Marcel de Matas,4 Muhammad Shahid,5 Muhammad Usman Minhas,6 Muhammad Sohail,7 Muhammad Khurram8 1Department of Pharmacy, University of Malakand, Chakdara, Pakistan ...
Ullah N, Khan S, Ahmed S, Govender T, Faidah HS, de Matas M, Shahid M, Minhas MU, Sohail M, Khurram M   +9 more
doaj  

Predicting the dissolution kinetics of silicate glasses using machine learning

, 2017
Predicting the dissolution rates of silicate glasses in aqueous conditions is a complex task as the underlying mechanism(s) remain poorly understood and the dissolution kinetics can depend on a large number of intrinsic and extrinsic factors.
Bauchy, Mathieu, Burton, Henry, Krishnan, N. M. Anoop, Mangalathu, Sujith, Smedskjaer, Morten M., Tandia, Adama   +5 more
core   +1 more source

Network-Based Vertex Dissolution [PDF]

, 2015
We introduce a graph-theoretic vertex dissolution model that applies to a number of redistribution scenarios such as gerrymandering in political districting or work balancing in an online situation.
Bredereck, Robert, Chen, Jiehua, Froese, Vincent, Niedermeier, Rolf, van Bevern, René, Woeginger, Gerhard J.   +5 more
core   +3 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Automation of Dissolution Tests [PDF]

Dissolution Technologies, 2000
Dissolution testing of drug formulations was introduced in the 1960s and accepted by health regulatory authorities in the 1970s. Since then, the importance of dissolution has grown rapidly as have the number of tests and demands in quality‐control laboratories.
openaire   +3 more sources

Interfacial dynamics in transport-limited dissolution

, 2006
Various model problems of ``transport-limited dissolution'' in two dimensions are analyzed using time-dependent conformal maps. For diffusion-limited dissolution (reverse Laplacian growth), several exact solutions are discussed for the smoothing of ...
G. H. Meyer, K. G. Kornev, K. Kornev, M. Z. Bazant, Martin Z. Bazant, S. D. Howsion, V. A. Maksimov   +6 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Characterization of Amorphous and Co-Amorphous Simvastatin Formulations Prepared by Spray Drying

Molecules, 2015
In this study, spray drying from aqueous solutions, using the surface-active agent sodium lauryl sulfate (SLS) as a solubilizer, was explored as a production method for co-amorphous simvastatin–lysine (SVS-LYS) at 1:1 molar mixtures, which previously ...
Goedele Craye, Korbinian Löbmann, Holger Grohganz, Thomas Rades, Riikka Laitinen   +4 more
doaj   +1 more source

Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3 [PDF]

, 2010
double Holliday junction (dHJ) is a central intermediate of homologous recombination that can be processed to yield crossover or non-crossover recombination products. To preserve genomic integrity, cells possess mechanisms to avoid crossing over. We show
C Gaillard, CF Chen, Csanad Z Bachrati, CZ Bachrati, CZ Bachrati, FG Harmon, FG Harmon, G Ira, HL Klein, Ian D Hickson, J German, J Plank, JC Wang, JC Wang, JK Karow, JL Plank, JL Plank, JL Plank, Jody L Plank, JR Mullen, L Bell, L Wu, L Wu, M Bzymek, M Chang, N Kantake, P Cejka, Petr Cejka, R Hanai, RS Chaganti, S Gangloff, S Raynard, S Raynard, Stephen C Kowalczykowski, TA Shapiro, TJ Fu, W Bussen, WD Heyer   +37 more
core   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source