Results 271 to 280 of about 261,203 (312)

Improved dissolution of ofloxacin via solid dispersion

International Journal of Pharmaceutics, 1997
Abstract The objective of this study was to improve the dissolution rate of a sparingly water soluble drug, ofloxacin, by solid dispersion systems with urea and mannitol. Differential scanning calorimetry (DSC), powder x-ray diffraction (PXRD) analysis and infrared spectroscopy (IR) were performed to evaluate the physicochemical properties of the ...
S Okonogi, T Oguchi, E Yonemochi, S Puttipipatkhachorn, K Yamamoto   +4 more
openaire   +1 more source

Characterization of ibuprofen microparticle and improvement of the dissolution

Pharmaceutical Development and Technology, 2016
The objective of this study was to prepare ibuprofen (IBP) microparticles by pH-change method and enhance the dissolution rate in vitro. Tween80 and Cremophor RH40 were selected as stabilizers to change the microparticles morphology. The microparticles were evaluated by dissolution profiles and characterized by differential scanning calorimetry (DSC ...
Fuzheng, Ren, Jianping, Su, Hui, Xiong, Ying, Tian, Guobin, Ren, Qiufang, Jing   +5 more
openaire   +2 more sources

Cellulose porosity improves its dissolution by facilitating solvent diffusion

International Journal of Biological Macromolecules, 2019
This paper reports on the effect of improved porous characteristics of cellulose on its solubility in DMAc/LiCl. The use of freeze-drying (FD) treatment led to higher surface area and void fraction of volume for high-molecular-weight (HMW) cotton cellulose (DP~5000).
Yang Hu, Sanjit Acharya, Noureddine Abidi   +2 more
openaire   +2 more sources

Improving Dissolution of Meloxicam Using Solid Dispersions

2006
Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. The aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (
Dehghan, MH, Jafar, M
openaire   +1 more source

Ibuprofen–phospholipid solid dispersions: Improved dissolution and gastric tolerance

International Journal of Pharmaceutics, 2012
Solid dispersions of ibuprofen with various phospholipids were prepared, and the effect of phospholipids on the in vitro dissolution and in vivo gastrointestinal toxicity of ibuprofen was evaluated. Most phospholipids improved the dissolution of ibuprofen; dimyristoylphosphatidyl-glycerol (DMPG) had the greatest effect.
M Delwar, Hussain, Vipin, Saxena, James F, Brausch, Rahmat M, Talukder   +3 more
openaire   +2 more sources

Naftopidil Molecular Salts with Improved Dissolution and Permeation

Crystal Growth & Design, 2020
Naftopidil (NFPD) is a α1 adrenoceptor antagonist drug. Low solubility and low permeability are the major drawbacks of this drug.
M. K. Chaitanya Mannava, Rambabu Dandela, Srinu Tothadi, K. Anand Solomon, Ashwini K. Nangia   +4 more
openaire   +1 more source

Improvement of nifedipine dissolution characteristics using supercritical CO2

International Journal of Pharmaceutics, 1997
Abstract An application of supercritical fluids (SCFs) for processing of pharmaceuticals is presented. PGSS (Particles from Gas Saturated Solutions), a novel method for high pressure material processing, has been used to improve technological characteristics of the poorly water soluble calcium antagonist nifedipine.
Petra Senčar-Božič, Stane Srčič, Zeljko Knez, Janez Kerč   +3 more
openaire   +1 more source

Rapamycin-cyclodextrin complexation: improved solubility and dissolution rate

Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2010
The objective of this study was to improve poor aqueous solubility and dissolution properties of anticancer drug rapamycin through formation of inclusion complexes with natural and modified cyclodextrins. Of the cyclodextrins tested, γ-cyclodextrin and hydroxypropyl-γ-cyclodextrin did not complex with rapamycin.
M. Abdur Rouf, Imran Vural, Erem Bilensoy, Atilla Hincal, Dilek Demir Erol   +4 more
openaire   +1 more source

Pharmaceutical cocrystals of naringenin with improved dissolution performance

CrystEngComm, 2018
Four pharmaceutical cocrystals of naringenin were obtained, which demonstrate improved dissolution performance.
Chun Luo, Wendong Liang, Xin Chen, Jianming Wang, Zongwu Deng, Hailu Zhang   +5 more
openaire   +1 more source

An Improved Method for Dissolution of Uranium Tetrafluoride.

Analytical Chemistry, 1962
Dissolution of UF/sub 4 in a mixture of (NH/sub 4/)/sub 2/ SO/sub 4/ and H/s ub 2/SO/sub 4/ and boric acid is described. For large-sized samples, addition of boric acid appreciably hastened dissolution, and a 15-gram sample was dissolved in 30 min in quartz glassware. The cooled melt is soluble in distilled water. (M.C.G.)
W. M. Wise, H. R. Soehnlin, C. H. McBride   +2 more
openaire   +1 more source