Results 281 to 290 of about 5,089,703 (351)

MCM-41 for furosemide dissolution improvement

Microporous and Mesoporous Materials, 2012
Abstract The ordered mesoporous silica material MCM-41 was used to prepare a novel drug delivery system (DDS) for oral administration of the diuretic furosemide (FURO), labeled in class IV of the Biopharmaceutics Classification System (BCS). This drug is characterized by both low solubility and permeability and its absorption window is the stomach ...
AMBROGI, Valeria, PERIOLI, Luana, PAGANO, CINZIA, LATTERINI, Loredana, MARMOTTINI, Fabio, RICCI, Maurizio, ROSSI, Carlo   +6 more
openaire   +3 more sources

Nanosizing Coamorphous Drugs Using Top-Down Approach: The Effect of Particle Size Reduction on Dissolution Improvement

AAPS PharmSciTech, 2022
Nanotechnology and coamorphous are both advanced technologies that can effectively improve the solubility of drugs. This study has been the first attempt to combine these two approaches to construct the coamorphous nanoparticles to improve the ...
Guoliang Wang, Yanchao Li, Zhiguo Qin, Tao Liu   +3 more
semanticscholar   +1 more source

Co-precipitates of Lumefantrine-Eudragit E PO for dissolution improvement.

Annales Pharmaceutiques Françaises, 2021
OBJECTIVES Lumefantrine, an antimalarial drug, is having poor solubility and variable bioavailability. This work is aimed to prepare and evaluate co-precipitate of lumefantrine-Eudragit E PO to improve its dissolution by anti-solvent precipitation ...
Rohit Patel, Sarika Wairkar
semanticscholar   +1 more source

Effects of the preparation technique on the physicochemical characteristics and dissolution improvement of ketoprofen-SBE7-β-CD binary inclusion complexes

, 2020
Ketoprofen (KTF) is classified as a biopharmaceutics classification system (BCS) class II drug owing to low aqueous solubility. To improve the solubility and dissolution profile of pure ketoprofen its inclusion complexes with sulfobutylether7-beta ...
S. Das, Soumalya Chakraborty, A. Bose, Rajan Rajabalaya, J. Khanam   +4 more
semanticscholar   +1 more source

Accelerated dissolution testing for improved quality assurance

Journal of Pharmaceutical and Biomedical Analysis, 2002
In pharmaceutical production of controlled release tablets and capsules, a rapid and automated at-line dissolution test for quality assurance of semi-products is advantageous. For effective control of the production, the analysis should not take more than about an hour, without loss of correlation to the ordinary (USP) dissolution test of the final ...
Per Ola, Quist, Göran, Ostling
openaire   +2 more sources

Improved dissolution behaviour of steam-granulated piroxicam

European Journal of Pharmaceutics and Biopharmaceutics, 2002
In this paper we prepared and characterized improved release granulates containing Piroxicam and beta-cyclodextrins (1:2.5 molar ratio), obtained by steam-aided granulation, using a one-step rotogranulator, Rotolab. These granulates were compared to those prepared by traditional wet granulation, to the physical mixture, and to the kneaded and dry ...
Cristina, Cavallari, Beatrice, Albertini, Marisa L, González-Rodríguez, Lorenzo, Rodriguez, Beatrice, Abertini   +4 more
openaire   +2 more sources

Improved Dissolution Rate of Indomethacin by Adsorbents

Drug Development and Industrial Pharmacy, 1998
Samples of indomethacin and kaolin or microcrystalline cellulose (Avicel) were prepared by solvent deposition or simple blending methods. Dissolution rates of these samples were studied. The surface adsorption of indomethacin on the studied adsorbents was shown to improve the dissolution rate of the drug in water.
S M, Alsaidan, A A, Alsughayer, A G, Eshra   +2 more
openaire   +2 more sources

Using biochemical system to improve cinnabar dissolution

Bioresource Technology, 2013
In order to evaluate the leaching of cinnabar, a chemobiological reactor system with Acidithiobacillus ferrooxidans for cinnabar dissolution was investigated. The results demonstrated cinnabar dissolution had relation to bioprocess of A. ferrooxidans and iron concentration tightly. The optimal dilution rate and iron concentration were 0.4/h and 2-3 g/L
Y J, Wang, H Y, Li, H F, Hu, D P, Li, Y J, Yang, C, Liu   +5 more
openaire   +2 more sources

Study on the dissolution improvement of albendazole using reconstitutable dry nanosuspension formulation

European Journal of Pharmaceutical Sciences, 2018
The aim of the study was to improve the solubility and dissolution rate of the poorly water soluble drug albendazole via surfactant assisted media milling process.
V. Fülöp, G. Jakab, Tamás Bozó, B. Tóth, Dániel Endrésik, E. Balogh, M. Kellermayer, I. Antal   +7 more
semanticscholar   +1 more source

Improved Holder for Intrinsic Dissolution Rate Studies

Journal of Pharmaceutical Sciences, 1965
An improved holder for use in rotational disk dissolution studies has been developed. The compression die becomes the rotating member. With it, the relative intrinsic dissolution rates at 37° in 0.1 N HC1 with 430 r.p.m. rotational speed have been found to be caffeine monohydrate, 106, aspirin, 9.73, salicylamide, 12.3, and acetaminophen, 41.7 ...
J, Wood, J, Syarto, H, Letterman
openaire   +2 more sources