Results 291 to 300 of about 5,089,703 (351)

Solubility and Dissolution Improvement of Carbamazepine by Various Methods

Research Journal of Pharmacy and Technology, 2019
This work was aimed to improve solubility and dissolution rate of carbamazepine (CBZ), an antiepileptic, BCS class II drug by using different solubility enhancement techniques.
Shreya, A. Heena, Ranjitha, A. Shetty, C. Mehta, U. Nayak, S. Mutalik, K. G. Pai   +7 more
semanticscholar   +1 more source

Porous and highly responsive cross-linked β-cyclodextrin based nanomatrices for improvement in drug dissolution and absorption.

Life Science, 2020
AIMS Aim of the study was to enhance the solubility of Chlorthalidone by developing beta-cyclodextrin cross-linked hydrophilic nanomatrices. MAIN METHODS Nine different formulations were fabricated by free radical polymerization technique.
S. Badshah, N. Akhtar, M. Minhas, K. Khan, Samiullah Khan, Orva Abdullah, Abid Naeem   +6 more
semanticscholar   +1 more source

Improved Dissolution Behavior of Fenbufen by Spherical Crystallization

Drug Development and Industrial Pharmacy, 1999
Fenbufen is an analgesic, antipyretic and anti-inflammatory drug that is characterized by poor water solubility, a defect increased by very low wettability. Poor water solubility, particularly at low pH, could decrease absorption in the upper part of the gastrointestinal tract, which would be inconvenient for good bioavailability.
DI MARTINO, Piera, C. Barthélémy, F. Piva, E. Joiris, PALMIERI, Giovanni Filippo, S. Martelli   +5 more
openaire   +3 more sources

Preparation and characterization of glimepiride eutectic mixture with L-arginine for improvement of dissolution rate.

International journal of pharmaceutics, 2020
In this study, glimepiride and L-arginine (GA) binary mixtures at various molar ratios were prepared to evaluate whether they could improve the poor water solubility and dissolution characteristics of glimepiride.
Heejun Park, H. Seo, Eun-Sol Ha, Seung-hyeon Hong, Jeong‐Soo Kim, Min‐Soo Kim, Sung-Joo Hwang   +6 more
semanticscholar   +1 more source

Improved dissolution of ofloxacin via solid dispersion

International Journal of Pharmaceutics, 1997
Abstract The objective of this study was to improve the dissolution rate of a sparingly water soluble drug, ofloxacin, by solid dispersion systems with urea and mannitol. Differential scanning calorimetry (DSC), powder x-ray diffraction (PXRD) analysis and infrared spectroscopy (IR) were performed to evaluate the physicochemical properties of the ...
S Okonogi, T Oguchi, E Yonemochi, S Puttipipatkhachorn, K Yamamoto   +4 more
openaire   +1 more source

Characterization of ibuprofen microparticle and improvement of the dissolution

Pharmaceutical Development and Technology, 2016
The objective of this study was to prepare ibuprofen (IBP) microparticles by pH-change method and enhance the dissolution rate in vitro. Tween80 and Cremophor RH40 were selected as stabilizers to change the microparticles morphology. The microparticles were evaluated by dissolution profiles and characterized by differential scanning calorimetry (DSC ...
Fuzheng, Ren, Jianping, Su, Hui, Xiong, Ying, Tian, Guobin, Ren, Qiufang, Jing   +5 more
openaire   +2 more sources

Investigation of drug-polymer miscibility, biorelevant dissolution, and bioavailability improvement of Dolutegravir-Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer solid dispersions.

European Journal of Pharmaceutical Sciences, 2019
The aim of the current study was to prepare the efficacious amorphous solid dispersion of poorly water-soluble compound, Dolutegravir. After theoretical and experimental determination of drug-polymer miscibility, polyvinyl caprolactam-polyvinyl acetate ...
D. Lakshman, Mohith Chegireddy, Geeta K. Hanegave, K. N. Sree, Naveen Kumar, S. Lewis, S. Dengale   +6 more
semanticscholar   +1 more source

Cellulose porosity improves its dissolution by facilitating solvent diffusion

International Journal of Biological Macromolecules, 2019
This paper reports on the effect of improved porous characteristics of cellulose on its solubility in DMAc/LiCl. The use of freeze-drying (FD) treatment led to higher surface area and void fraction of volume for high-molecular-weight (HMW) cotton cellulose (DP~5000).
Yang Hu, Sanjit Acharya, Noureddine Abidi   +2 more
openaire   +2 more sources

Preparation, characterization, and evaluation of celecoxib eutectic mixtures with adipic acid/saccharin for improvement of wettability and dissolution rate

International journal of pharmaceutics, 2019
Graphical abstract Figure. No caption available. Abstract Celecoxib (CEL) is a selective cyclooxygenase‐2 (COX‐2) inhibitor therapeutically indicated for the treatment of rheumatoid arthritis, osteoarthritis, acute pain, and inflammation.
Sang-Min Hyun, B. Lee, S. Abuzar, Soo-Ran Lee, Yechan Joo, Seung-hyeon Hong, Han Kang, K. Kwon, S. Velaga, Sung-Joo Hwang   +9 more
semanticscholar   +1 more source

Improvement of the dissolution rate and bioavailability of fenofibrate by the supercritical anti-solvent process.

International journal of pharmaceutics, 2019
The purpose of this study was to improve solubility and oral bioavailability of fenofibrate via solid dispersion (SD) using a supercritical anti-solvent (SAS) process with amphipathic polymers P407 and TPGS.
Jung Bin Ahn, Dong-Hyun Kim, Sang-eun Lee, Yong-Chul Pyo, Jeong-Sook Park   +4 more
semanticscholar   +1 more source