Results 251 to 260 of about 177,103 (312)

Spatiotemporal Drug Delivery via a Neonatal Spinal Cord ECM Hydrogel for Biomimetic Microenvironment Remodeling After Spinal Cord Injury

Advanced Functional Materials, EarlyView.
A biomimetic hydrogel derived from neonatal spinal cord ECM (DNSCM) delivers LAMB2 protein and ISP peptide to remodel the inhibitory injury microenvironment. The system sustains drug release, upregulates pro‐regenerative LAMB2, downregulates inhibitory CSPG, and promotes axonal regeneration.
Shiyu Fu, Liangchao Du, Runlin Wen, Kai Zhang, Yu Zhou, Wanrong Ma, Zhiquan Yang, Dingyang Liu, Xing Li   +8 more
wiley   +1 more source

Engineering Pendant Group Chemistry to Control Hydrophilicity and Oxidative Degradation of Thioketal‐Based Biomaterials

Advanced Functional Materials, EarlyView.
Thioketal (TK) polymers are promising biomaterials due to their selective biodegradation by reactive oxygen species (ROS), but they respond slowly to physiologic doses of ROS. Here, the TK bond's pendant groups are modified to enhance the degradation of TK‐based implants both in vitro and in vivo.
Karina A. Bruce, Dylan W. Marques, Alan J. Fullenkamp, Emma‐Louise Lowell, Rais B. Fataki, Jake D. Ryan, John R. Martin   +6 more
wiley   +1 more source

Nanoengineered Binetworks in Multifunctional Anionic Block Polymer Mesoblends for Improved Mechanical Properties

Advanced Functional Materials, EarlyView.
Mesoblends consist of a nanostructured polymer into which a second polymer is imbibed with a selective solvent. In this work, a solvent‐templatable pentablock terpolymer possessing a sulfonated midblock is modified with a hydrophilic polymer that is photocrosslinked in situ, yielding a hierarchical binetwork.
Kacie M. Wells, Ivan Kuzmenko, Reza A. Ghiladi, Richard J. Spontak   +3 more
wiley   +1 more source

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Microneedles with Tunable Dissolution Rate

ACS Biomaterials Science & Engineering, 2020
Dissolvable microneedle (MN) patches have been widely investigated for transdermal drug delivery. The dissolution rate of MN controls the status of drug release from the MN, which in turn determines drug absorption through skin. However, no systematic approaches have been reported to tune the dissolution profile of dissolvable MN matrices.
Himanshu Kathuria, Dennis Lim, Junyu Cai, Bong Geun Chung, Lifeng Kang   +4 more
openaire   +2 more sources

Dissolution Rate Equations in CoIumn-Confined Dissolution

Journal of Pharmaceutical Sciences, 1976
Equations are derived for the dissolution of a soluble solid in a column into a liquid stream. The equations are substantiated by experiments using oxalic acid dihydrate as a test substance. The dissolution rate constant, k, of oxalic acid dihydrate depends on linear velocity, v (centimeters per second), by the following equation: k = (2.54 +/- 0.76) X
J T, Carstensen, K, Dhupar
openaire   +2 more sources

Dissolution Rates of Polyphase Mixtures

Journal of Pharmaceutical Sciences, 1965
The theory for the dissolution rate of polyphase mixtures has been investigated and applied to several situations. Physical models involving simultaneous diffusion and rapid equilibria have led to relationships that describe experimental data rather well for the benzoic acid–salicylic acid, the benzocaine–caffeine, and the benzoic acid–trisodium ...
W I, Higuchi, N A, Mir, S J, Desai
openaire   +2 more sources

Dissolution rates of silicate cements

Biomaterials, 1982
The literature relating to the dissolution of the silicate cements is reviewed, including the methodology, intrinsic factors relating to composition and method of mixing, curing etc. and extrinsic factors, i.e. the medium, pH, ionic strength etc. to which the sample of cement is exposed.
A T, Kuhn, G B, Winter, W K, Tan
openaire   +2 more sources

Nonsink Dissolution Rate Equations

Journal of Pharmaceutical Sciences, 1975
In spite of the fact that film theory is based on severe assumptionss, it is shown to be a good working model. The Niebergall-Goyan equation, the Short-Sharkey-Rhodes equation, and the Pothisiri-Carstensen equation-all based on simple film theory-are shown to hold through 80-90% of the dissolutin process for p-hydroxybenzoic acid and sodium chloride ...
M, Patel, J T, Carstensen
openaire   +2 more sources

Nonsink Dissolution Rate Equation

Journal of Pharmaceutical Sciences, 1973
An equation was developed which describes the dissolution of monodisperse particles beyond the point where concentrations are small compared to solubility. If it is assumed that a stagnant layer model applies, the thickness of these layers is of the same order of magnitude as calculated via the Hixson-Crowell treatment but dissolution rate constants ...
P, Pothisiri, J T, Carstensen
openaire   +2 more sources

Controlled Release with Finite Dissolution Rate

SIAM Journal on Applied Mathematics, 2011
We consider a two-phase generalization of the classical Higuchi model for controlled drug release. The drug is assumed to be prepared in a stent in its solid phase by immersion in a polymeric matrix, which eventually delivers the drug when it reaches the free end.
BISCARI, PAOLO, S. Minisini, PIEROTTI, DARIO GIANCARLO, VERZINI, GIANMARIA, ZUNINO, PAOLO   +4 more
openaire   +2 more sources