Results 261 to 270 of about 5,482,491 (310)

Dissolution Rate of Cholesterol in Monooctanoin

Hepatology, 1984
Monooctanoin is used clinically for dissolution of common bile duct cholesterol gallstones. A number of factors influencing the dissolution rate of cholesterol monohydrate in this solvent were investigated. Water increased cholesterol dissolution rate in a manner inconsistent with previous solubility measurements.
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Dissolution Modeling: Factors Affecting the Dissolution Rates of Polydisperse Powders

Pharmaceutical Research, 1993
The dissolution rates of two lots of hydrocortisone (fine and coarse) were simulated using a computer program based on a Noyes-Whitney-type equation. Derivations of the equation were made to compare the accuracy of simulations using spherical and cylindrical particle geometry, with and without a time-dependent diffusion layer thickness.
A T, Lu, M E, Frisella, K C, Johnson
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Variation of Crystal Dissolution Rate Based on a Dissolution Stepwave Model

Science, 2001
A formulation based on defect-generated dissolution stepwaves of the variation of dissolution rate with the degree of undersaturation is validated by near-atomic-scale observations of surfaces, Monte Carlo simulations, and experimental bulk dissolution rates.
A C, Lasaga, A, Luttge
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Dissolution Rates under Sink Conditions

Journal of Pharmaceutical Sciences, 1971
Abstract Equations are given for the dissolution of a drug into an aqueous phase overlayered with a lipid phase, in which back transfer from the lipid phase is assumed possible. Consideration of both the presence and absence of back transfer, assuming in each that the amount of drug in the aqueous phase either approaches saturation or remains ...
P J, Niebergall, E T, Sugita, R L, Schnaare   +2 more
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Solubility and Dissolution Rates in Reactive Media

Journal of Pharmaceutical Sciences, 1964
The relationship between the diffusion-controlled dissolution rate of a substance in a reactive medium and the solubility of the substance in the medium has been analyzed. The results reconcile the total solubility method and the simultaneous diffusion and chemical reaction method of interpreting data on dissolution rates.
W I, HIGUCHI, E, NELSON, J G, WAGNER
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Influence of Viscosity and Solubilization on Dissolution Rate

Journal of Pharmaceutical Sciences, 1972
Abstract The dissolution rate of benzoic acid in aqueous sucrose and methylcellulose solutions is inversely proportional to the viscosity of the dissolution medium. The total solubility of benzoic acid in aqueous solutions of polysorbate 80 increases linearly as the concentration of the surfactant is increased.
R J, Braun, E L, Parrott
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Regulation of Dissolution Rate by Pellet Geometry

Journal of Pharmaceutical Sciences, 1969
The influence of surface configuration on the dissolution behavior of pellets suspended in a turbulent flow field has been investigated. The rate of dissolution of extruded cellulose acetate hydrogen phthalate pellets was found to be a complex function of surface geometry.
E G, Rippie, J R, Johnson
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System for Automated Determination of Dissolution Rate

Journal of Pharmaceutical Sciences, 1974
Abstract An automated dissolution rate apparatus meeting requirements of the USP–NF dissolution test and applicable to various other agitation systems in common usage is described. The equipment allows simultaneous determination of the dissolution rate of six unit doses, enabling evaluation of a statistically significant number of samples. The system,
J B, Johnson, P G, Kennedy, S H, Rubin
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Dissolution Rates of Pure Nonionic Surfactants

Langmuir, 2000
no ...
Chen, B. H., Miller, C. A., Walsh, J. M., Warren, P. B., Ruddock, J. N., Garrett, P. R., Argoul, Françoise, Léger, Christophe   +7 more
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Dissolution Rate Studies on Methylprednisolone Polymorphs

Journal of Pharmaceutical Sciences, 1964
Dissolution rates (DR) of methylprednisolone polymorphs I and II were determined by the rotating disk method as a function of rate of rotation (RR). The results show that the DR-RR relationship differs from that normally expected in the case of diffusion-controlled dissolution from rotating disks.
G, LEVY, J A, PROCKNAL
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