Results 41 to 50 of about 136,291 (302)

Statistical Properties of the Dissolution Test of USP [PDF]

, 2004
The dissolution test as defined in the United States Phar-macopoeia (1) is used in judging the quality of pharma-ceutical products. Dissolution testing is a method for evaluating physiological availability that depends upon having the drug in a dissolved
Carlos D. Saccone, Julio Tessore, Nora S. Meneces, Silvino A. Olivera   +3 more
core  

Effect of particle size on release of solid dispersed particles during the "Dissolution" test

Разработка и регистрация лекарственных средств
Introduction. The use of the solid disperse systems method to increase the solubility of lipophilic active pharmaceutical ingredients is industrially applicable using different technologies, but the influence of particle size on the dissolution of these ...
S. A. Zolotov, A. V. Panov
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Development of Modified Drug Delivery Systems with Metformin Loaded in Mesoporous Silica Matrices: Experimental and Theoretical Designs

Pharmaceutics
Background/Objectives: Mesoporous silica materials, particularly KIT-6, offer promising features, such as large surface area, tunable pore structures, and biocompatibility, making them ideal candidates for advanced drug delivery systems. The aims of this
Mousa Sha’at, Maria Ignat, Florica Doroftei, Vlad Ghizdovat, Maricel Agop, Alexandra Barsan (Bujor), Monica Stamate Cretan, Fawzia Sha’at, Ramona-Daniela Pavaloiu, Adrian Florin Spac, Lacramioara Ochiuz, Carmen Nicoleta Filip, Ovidiu Popa   +12 more
doaj   +1 more source

Potentiometric Membrane Sensors for the Selective Determination of Memantine Hydrochloride in Pharmaceutical Preparations

International Journal of Electrochemical Science, 2012
Three potentiometric sensors responsive to Memantine HCl (MEM) drug are described, characterized, compared and used for drug assessment. The sensors are based on the use of the ion-association complex of (MEM) cation with Flavianate (FA), 5-Nitro ...
Rasha M. El Nashar, Aliaa S.M. El-Tantawy, Saad S.M. Hassan   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release [PDF]

, 2014
The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble com-pounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to im-prove their
González Vidal, Noelia Luján, Castro, Silvina Gabriela, Sanchez Bruni, Sergio Fabian, Allemandi, Daniel Alberto, Palma, Santiago Daniel   +4 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Intrinsic Dissolution as a Tool for Evaluating Drug Solubility in Accordance with the Biopharmaceutics Classification System

, 2011
The Biopharmaceutics Classification System (BCS) is a tool that was created to categorize drugs into different groups according to their solubility and permeability characteristics.
ISSA, Michele G., FERRAZ, Humberto G.
core   +1 more source