Results 41 to 50 of about 475,693 (306)

Effect of particle size on release of solid dispersed particles during the "Dissolution" test

Разработка и регистрация лекарственных средств
Introduction. The use of the solid disperse systems method to increase the solubility of lipophilic active pharmaceutical ingredients is industrially applicable using different technologies, but the influence of particle size on the dissolution of these ...
S. A. Zolotov, A. V. Panov
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Profil Disolusi dan Penetapan Kadar Tablet Meloksikam Inovator dan Generik Bermerek dengan Kckt (Kromatografi Cair Kinerja Tinggi) [PDF]

, 2010
. The determination of meloxicam and the dissolution test has been done. Drug dissolution test is an approach to evaluate drug release characteristics of product (Tablets/capsules) in vitro.
Mutiatikum, D. (D), Raini, M. (Mariana)
core  

Predicting the dissolution kinetics of silicate glasses using machine learning

, 2017
Predicting the dissolution rates of silicate glasses in aqueous conditions is a complex task as the underlying mechanism(s) remain poorly understood and the dissolution kinetics can depend on a large number of intrinsic and extrinsic factors.
Bauchy, Mathieu, Burton, Henry, Krishnan, N. M. Anoop, Mangalathu, Sujith, Smedskjaer, Morten M., Tandia, Adama   +5 more
core   +1 more source

Quality of medicines commonly used in the treatment of soil transmitted helminths and Giardia in Ethiopia: a nationwide survey [PDF]

, 2014
Background: The presence of poor quality medicines in the market is a global threat on public health, especially in developing countries. Therefore, we assessed the quality of two commonly used anthelminthic drugs [mebendazole (MEB) and albendazole (ALB)]
D'Hondt, Matthias, De Spiegeleer, Bart, Deti, Habtewold, Duchateau, Luc, Levecke, Bruno, Mekonnen Kurmane, Zeleke, Vercruysse, Jozef, Wega, Sultan Suleman, Wynendaele, Evelien, Zeleke, Gemechu   +9 more
core   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Development of Modified Drug Delivery Systems with Metformin Loaded in Mesoporous Silica Matrices: Experimental and Theoretical Designs

Pharmaceutics
Background/Objectives: Mesoporous silica materials, particularly KIT-6, offer promising features, such as large surface area, tunable pore structures, and biocompatibility, making them ideal candidates for advanced drug delivery systems. The aims of this
Mousa Sha’at, Maria Ignat, Florica Doroftei, Vlad Ghizdovat, Maricel Agop, Alexandra Barsan (Bujor), Monica Stamate Cretan, Fawzia Sha’at, Ramona-Daniela Pavaloiu, Adrian Florin Spac, Lacramioara Ochiuz, Carmen Nicoleta Filip, Ovidiu Popa   +12 more
doaj   +1 more source

Development and validation of a stability-indicating HPLC method for the determination of buclizine hydrochloride in tablets and oral suspension and its application to dissolution studies

Química Nova, 2012
A method using liquid chromatography has been developed and validated for determination of buclizine in pharmaceutical formulations and in release studies.
Gislaine Kuminek, Hellen K. Stulzer, Monika P. Tagliari, Paulo R. Oliveira, Larissa S. Bernardi, Gabriela Rauber, Simone G. Cardoso   +6 more
doaj   +1 more source

Family Structure and the Economic Wellbeing of Children [PDF]

, 2012
An extensive literature that examines the relationship between family structure and children's outcomes consistently shows that living with a single parent is associated with negative outcomes. Few studies, however, directly test the relationship between
Leonard M. Lopoo, Thomas DeLeire
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source