Results 51 to 60 of about 6,915,672 (299)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Statistical Properties of the Dissolution Test of USP [PDF]
, 2004 The dissolution test as defined in the United States Phar-macopoeia (1) is used in judging the quality of pharma-ceutical products. Dissolution testing is a method for evaluating physiological availability that depends upon having the drug in a dissolved
Carlos D. Saccone +3 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Разработка и регистрация лекарственных средств, 2020 Introduction. An innovative pharmaceutical substance based on the 3,7-diazabicyclo[3.3.1]nonane derivative provides long-term activation of AMPA receptors and the production of neurotrophic factors, which makes it possible to use it for the treatment of ...
G. E. Brkich +5 more
doaj +1 more source
Challenges in Dissolution Testing
Dissolution Technologies, 2012 Dissolution testing of dosage forms is an activity in continuous development, both for improving equipment and its performance qualification and for selecting the best test conditions. The U. S. Pharmacopeia (USP) held a workshop coordinated by some USP expert panels at its headquarters in Rockville, MD, on June 11 and 12, 2012, to present and discuss ...
Margareth R. C. Marques +7 more
openaire +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
USE OF DISSOLUTION TEST FOR EVALUATION OF PHARMACEUTICAL EQUIVALENCE OF ATORVASTATIN GENERICS
Разработка и регистрация лекарственных средств, 2019 This article shows the results of a study of pharmaceutical equivalence of atorvastatin generics using Dissolution test. A significant difference in the intensity of atorvastatin release from tablets from different manufacturers has been established ...
O. V. Druzhininskaya, I. E. Smekhova
doaj