Results 51 to 60 of about 475,693 (306)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Pengaruh Milling Terhadap Laju Disolusi Campuran Metampiron-fenilbutason (7:3) [PDF]
, 2007 In pharmaceutical process, milling is a common process to produce particle in certain expectation size. Impact of milling process could lead to physical interaction.Dissolution rate will change as an impact of physical interaction.
Haryana, A. (Aris) +1 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Разработка и регистрация лекарственных средств, 2020 Introduction. An innovative pharmaceutical substance based on the 3,7-diazabicyclo[3.3.1]nonane derivative provides long-term activation of AMPA receptors and the production of neurotrophic factors, which makes it possible to use it for the treatment of ...
G. E. Brkich +5 more
doaj +1 more source
Dissolution and Mechanical properties of Bioresorbable Glass Fibres for use in Paediatric tracheal stents [PDF]
, 2015 Stents provide biological support in body conduits and are useful for counteracting stenosis (constriction) in cardiovascular, gastrointestinal, uretheral and airway passages1.
Adekanmbi, Isaiah +3 more
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Marine-friendly antifouling coating based on the use of a fatty acid derivative as a pigment [PDF]
, 2014 This study was devoted to examining the application of copper dodecanoate as a non-contaminant antifouling pigment due to its low copper content and fatty acid nature.
Alemán Llansó, Carlos +4 more
core +2 more sources
Investigation of the Incompatibilities of Cement and Superplasticizers and Their Influence on the Rheological Behavior [PDF]
, 2020 The rheological behavior of cement paste and the improvement of its flowability takes center stage in many research projects. An improved flowability can be achieved by the addition of superplasticizers (SP), such as polycarboxylate ethers (PCE).
Jakob, Cordula +4 more
core +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The role of phospholipid as a solubility- and permeability-enhancing excipient for the improved delivery of the bioactive phytoconstituents of Bacopa monnieri [PDF]
, 2016 In an attempt to improve the solubility and permeability of Standardized Bacopa Extract (SBE), a complexation approach based on phospholipid was employed.
Bobde, Yamini S +6 more
core +2 more sources