Development of a Predictive Flow Through Cell Dissolution Method for Carbamazepine Modified‐Release Tablets [PDF]
CPT: Pharmacometrics & Systems PharmacologyPredictive in vitro dissolution methods are crucial for anticipating in vivo drug performance, particularly for poorly soluble drugs like carbamazepine.
Laura Carvajal Barbosa +2 more
doaj +2 more sources
Improving In Vitro–In Vivo Correlation (IVIVC) for Lipid-Based Formulations: Overcoming Challenges and Exploring Opportunities [PDF]
PharmaceuticsLipid-based formulations (LBFs) play a crucial role in enhancing the oral bioavailability of poorly water-soluble drugs by leveraging lipid digestion and solubilization processes. However, developing robust in vitro–in vivo correlations (IVIVCs) for LBFs
Arnaud Bourderi-Cambon +7 more
doaj +2 more sources
Development and Evaluation of Bilayer Sustained-Release Tablets of Ruxolitinib Using Discriminative Pharmacokinetic Analysis and IVIVC [PDF]
PharmaceuticsObjectives: This study explores the development and evaluation of a bilayer sustained-release (SR) tablet formulation of ruxolitinib. As a BCS Class 1 drug, ruxolitinib requires twice-daily dosing due to its short half-life.
Namhyuck Kim +6 more
doaj +2 more sources
Future Journal of Pharmaceutical Sciences, 2018 A key approach in development of any pharmaceutical dosage form is to establish applicability and assuring the quality safety of its product. IVIVC establishes an important link between the in-vitro dissolution and the in-vivo release of the drug under ...
Vaibhav Rastogi +2 more
exaly +3 more sources
Compositional profiling for biodegradable medical devices: a framework for degradation-informed exposure and risk assessment [PDF]
Frontiers in ToxicologyBiodegradable polymers (BPs) present unique challenges for chemical characterization and toxicological risk assessment. Methodological requirements for devices with prolonged tissue contact often involve exhaustive extraction—an approach impractical for ...
Jared Wilsey +8 more
doaj +2 more sources
Developing In Vitro–In Vivo Correlation for Bicalutamide Immediate-Release Dosage Forms with the Biphasic In Vitro Dissolution Test [PDF]
PharmaceuticsBackground/Objectives: Reflecting the interaction between dissolution and absorption, the biphasic dissolution system is an appealing approach for estimating the intestinal absorption of drugs in humans.
Nihal Tugce Ozaksun, Tuba Incecayir
doaj +2 more sources
A convolution‐based in vitro‐in vivo correlation model for methylphenidate hydrochloride delayed‐release and extended‐release capsule [PDF]
CPT: Pharmacometrics & Systems PharmacologyDelayed‐release and extended‐release methylphenidate hydrochloride (JORNAY PM®) is a novel capsule formulation of methylphenidate hydrochloride, used to treat attention deficit hyperactivity disorder in patients 6 years and older.
Pawan Kumar Gupta +3 more
doaj +2 more sources
In Vitro Evaluation of Poly(D,L-lactide-co-glycolide) In Situ Gels and Pharmacokinetics Following Subcutaneous Injection in Rats for Model Drugs [PDF]
PharmaceuticsBackground/Objectives. This research supports the development of long-acting injectables (LAIs) via in situ gel (ISG) technology by illustrating the influence of drug properties and formulation variables on in vitro drug release (Part 1), and providing ...
Sandy Van Hemelryck +7 more
doaj +2 more sources
The Evolving Role of In Vitro–In Vivo Correlation in Model‐Informed Drug Development: A Multi‐Stakeholder Perspective [PDF]
CPT: Pharmacometrics & Systems PharmacologyIn vitro–in vivo correlation/relationship (IVIVC/R) models such as physiologically based biopharmaceutics modeling (PBBM) are crucial tools that link biopharmaceutical properties to clinical performance.
Marylore Chenel +7 more
doaj +2 more sources
Physiologically-Based Pharmacokinetic Modeling and In Vitro–In Vivo Correlation of TV-46000 (Risperidone LAI): Prediction from Dog to Human [PDF]
PharmaceuticsThe interest in the development and therapeutic application of long-acting injectable products for chronic or long-term treatments has experienced exponential growth in recent decades.
David Bibi +3 more
doaj +2 more sources