Results 11 to 20 of about 1,005 (158)

Establishment of Level a In Vitro–In Vivo Correlation (IVIVC) via Extended DoE-IVIVC Model: A Donepezil Case Study

Pharmaceutics, 2022
This study aimed to establish an extended design of experiment (DoE)-in vitro in vivo correlation (IVIVC) model that defines the relationship between formulation composition, in vitro dissolution, and in vivo pharmacokinetics. Fourteen sustained-release (
Da Young Lee, Soyoung Shin, Tae Hwan Kim, Beom Soo Shin   +3 more
doaj   +3 more sources

In vitro-in vivo correlation (IVIVC) of different parameters of dosage form

Journal of Contemporary Pharmacy, 2021
Researchers can achieve rapid drug production by discovering a mathematical link between bioavailability and dissolution testing that leads to the principle of in vitro - in vivo correlation (IVIVC). IVIVC is a mathematical model which from its in vitro
Shazia Ashraf, Azka Ali, Uzma Noreen, Iqra Abdullah Jan   +3 more
doaj   +2 more sources

IVIVC from Long Acting Olanzapine Microspheres [PDF]

International Journal of Biomaterials, 2014
In this study, four PLGA microsphere formulations of Olanzapine were characterized on the basis of their in vitro behavior at 37°C, using a dialysis based method, with the goal of obtaining an IVIVC.
Susan D'Souza, Jabar A. Faraj, Stefano Giovagnoli, Patrick P. DeLuca   +3 more
doaj   +3 more sources

Establishment of Dissolution Test Method for Multi-Components in Traditional Chinese Medicine Preparations Based on In Vitro–In Vivo Correlation [PDF]

Pharmaceuticals
In this study, a multi-component integrated dissolution evaluation system of Yuanhu Zhitong tablets (YZTs) was established based on in vitro and in vivo correlation (IVIVC).
Pengcheng Guo, Qizheng Wang, Xiaoqiang Xiang, Yufeng Zhang, Yue Pan, Zhong Zuo, Jianxin Wang   +6 more
doaj   +2 more sources

Surfactants Significantly Improved the Oral Bioavailability of Curcumin Amorphous Solid Dispersions and Its Underlying Mechanism [PDF]

Pharmaceutics
Background/Objectives: Surfactants are commonly used in amorphous solid dispersions (ASDs) to improve drug dissolution. A mechanistic understanding of their impact on in vitro dissolution and in vivo pharmacokinetics is essential for rational ASD design ...
Jinhua Yuan, Siyi Mao, Xiuzhen Ma, Xiaoling Liu, Yuejie Chen   +4 more
doaj   +2 more sources

In vitro-in vivo correlation (IVIVC) development for long-acting injectable drug products based on poly(lactide-co-glycolide) [PDF]

Journal of Controlled Release
Andrew Otte, Kinam Park
exaly   +2 more sources

Model-Informed Paradigm in Drug Development-An End-To-End Case Study From Upadacitinib Development. [PDF]

Clin Transl Sci
ABSTRACT Model‐informed drug development (MIDD) entails applying quantitative approaches to assist with decision‐making during drug development and has been used for dose optimization, to inform clinical trial design, and to support clinical trial waivers.
Bhatnagar S, Stodtmann S, Qian Y, Marroum P, Liu W, Mohamed MF.   +5 more
europepmc   +2 more sources

One and Two-Step In Vitro-In Vivo Correlations Based on USP IV Dynamic Dissolution Applied to Four Sodium Montelukast Products

Pharmaceutics, 2021
Montelukast is a weak acid drug characterized by its low solubility in the range of pH 1.2 to 4.5, which may lead to dissolution-limited absorption. The aim of this paper is to develop an in vivo predictive dissolution method for montelukast and to check
Mercedes Prieto-Escolar, Juan J. Torrado, Covadonga Álvarez, Alejandro Ruiz-Picazo, Marta Simón-Vázquez, Carlos Govantes, Jesús Frias, Alfredo García-Arieta, Isabel Gonzalez-Alvarez, Marival Bermejo   +9 more
doaj   +1 more source

Evaluating the bioequivalence of two pitavastatin calcium formulations based on IVIVC modeling and clinical study

Clinical and Translational Science, 2023
In vitro‐in vivo correlation (IVIVC) allows prediction of the in vivo performance of a pharmaceutical product based on its in vitro drug release profiles and can be used to reduce the number of bioequivalence (BE) studies during product development, and ...
Jiaying Wang, Jinliang Chen, Lu Wang, Dandan Yang, Rong Shao, Honggang Lou, Zourong Ruan, Bo Jiang   +7 more
doaj   +1 more source

In vivo dissolution of poorly water-soluble drugs: Proof of concept based on fluorescence bioimaging

Acta Pharmaceutica Sinica B, 2021
In vitro‒in vivo correlation (IVIVC) of solid dosage forms should be established basically between in vitro and in vivo dissolution of active pharmaceutical ingredients. Nevertheless, in vivo dissolution profiles have never been accurately portrayed. The
Yinqian Yang, Yongjiu Lv, Chengying Shen, Tingting Shi, Haisheng He, Jianping Qi, Xiaochun Dong, Weili Zhao, Yi Lu, Wei Wu   +9 more
doaj   +1 more source