Results 41 to 50 of about 1,005 (158)

Biowaiver Based on the Biopharmaceutical Classification System: Regulatory Basis and Limits of Scientific Interpretation (Review)

Регуляторные исследования и экспертиза лекарственных средств
INRODUCTION. Biowaiver procedure based on the biopharmaceutics classification system (BCS) is widely used in regulatory practice when assessing the bioequivalence of generic medicinal products (GMPs).
N. J. Dahma, E. T. Zhilyakova, D. A. Fadeeva, M. J. Dahma, R. Alrouhayyah, K. A. Nikitin   +5 more
doaj   +1 more source

In Vitro – In Vivo Correlation of Pentoxifylline: A Comprehensive Kinetic Analysis

Studia Universitatis Babes-Bolyai Chemia
This study presents an analysis of In Vitro-In Vivo Correlation (IVIVC) for pentoxifylline modified-release tablets, with a focus on deriving robust predictive models.
Maria CODREANU, Diana IACOB, Maria Ioana ONOFREI, Ana-Maria VLASE, Dana Maria MUNTEAN, Laurian VLASE   +5 more
doaj   +1 more source

In vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability

Journal of Pharmaceutical Analysis, 2015
Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk.
Baishakhi Dey, Prakash Katakam, Fathi H. Assaleh, Babu Rao Chandu, Shanta Kumari Adiki, Analava Mitra   +5 more
doaj   +1 more source

Integration of Machine Learning With PBPK and QSAR Modeling Approaches to Facilitate Drug Discovery and Development

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 4, April 2026.
ABSTRACT This review examines the application of machine learning (ML) in physiologically based pharmacokinetic (PBPK) modeling through improved prediction of input parameters, particularly via quantitative structure–activity relationship (QSAR) models, for absorption, distribution, metabolism, and excretion (ADME) properties across drug development ...
Xinyue Chen, Zhoumeng Lin
wiley   +1 more source

An overview of the alarming impediments encountered while establishing an apposite IVIVC of nanomedicines necessitated its regulatory approval

OpenNano
For the past three decades, the principle of nanotechnology has been widely employed to develop pharmaceuticals and bio-pharmaceuticals that are successful for many disease therapies.
Nandakumar Selvasudha, Joseph Pushpa Sweety, Gover Antoniraj M, Kandasamy Ruckmani   +3 more
doaj   +1 more source

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

Med Research, Volume 2, Issue 1, Page 130-156, March 2026.
The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal   +3 more
wiley   +1 more source

Modeling Polymeric Drug Release: The Emerging Role of Machine Learning

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
A review of mechanistic, empirical, and machine learning (ML) approaches for modeling drug release from polymeric systems, highlighting how data‐driven methods uncover relationships between formulation parameters and release behavior to guide future drug delivery design.
Ryan N. Woodring, Kristy M. Ainslie
wiley   +1 more source

Microsponge-derived mini tablets loaded with immunosuppressive agents: Pharmacokinetic investigation in human volunteers, cell viability and IVIVC correlation

Saudi Pharmaceutical Journal, 2023
Sirolimus, a potent immunosuppressant, has been demonstrated to have remarkable activity in inhibiting allograft rejection in transplantation.
Yasir Mehmood, Hira Shahid, Muhammad Abbas, Umar Farooq, Shaukat Ali, Mohsin Kazi   +5 more
doaj   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Establishing Prospective IVIVC for Generic Pharmaceuticals: Methodologies Assessment [PDF]

The Open Drug Delivery Journal, 2014
The present study was aimed to establish prospective IVIVC method for generic products using example of two different drug formulations (aprepitant capsules, immediate release and donepezil tablets, sustained release). The in vitro dissolution of these formulations was examined by using USP-II apparatus and different range of dissolution media.
Sumon Chakraborty, Kavan Pandya, Deepika Aggarwal   +2 more
openaire   +1 more source