Results 61 to 70 of about 1,005 (158)
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 9, Page 1421-1430, September 2025.ABSTRACT The U.S. Food and Drug Administration (FDA) publishes product‐specific guidances (PSGs), with bioequivalence (BE) recommendations for prospective generics. Developing BE recommendations for non‐orally administered drug products including long‐acting injectables (LAI), orally inhaled drug products, and drugs applied locally to the skin ...
Steven G. Chopski +6 more
wiley +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2012 Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo ...
Mohammad Barzegar-Jalali +6 more
doaj +1 more source
Small, Volume 21, Issue 29, July 24, 2025.This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai +5 more
wiley +1 more source
WIREs Nanomedicine and Nanobiotechnology, Volume 17, Issue 3, May/June 2025.The field of cancer nanomedicine has seen tremendous advancements over the last two decades, not only in the nanotechnologies themselves, but in the applications and uses of these novel nanomaterials and the characterization techniques employed to better understand both their physicochemical and biological properties. AI, artificial intelligence; QSAR,
Rachael M. Crist +29 more
wiley +1 more source
In vitro-in vivo correlations (IVIVCs) of deposition for drugs given by oral inhalation
Advanced Drug Delivery Reviews, 2020 Conventional in vitro tests to assess the aerodynamic particle size distribution (APSD) from inhaler devices use simple right-angle inlets ("mouth-throats", MTs) to cascade impactors, and air is drawn through the system at a fixed flow for a fixed time.
Stephen P, Newman, Hak-Kim, Chan
openaire +2 more sources
Clinical and Translational Science, Volume 18, Issue 1, January 2025.ABSTRACT The pharmaceutical industry constantly strives to improve drug development processes to reduce costs, increase efficiencies, and enhance therapeutic outcomes for patients. Model‐Informed Drug Development (MIDD) uses mathematical models to simulate intricate processes involved in drug absorption, distribution, metabolism, and excretion, as well
Karthik Raman +3 more
wiley +1 more source
Advanced Functional Materials, Volume 34, Issue 40, October 1, 2024.A multifunctional oral drug delivery vehicle is engineered to overcome the multifaceted challenges of antipsychotic drugs, including their poor bioavailability and impact on the gut‐brain axis. Inulin‐lipid microcapsules facilitated an increase in lurasidone absorption by increasing drug solubility while targeting the gut microbiota increased microbial
Tahlia R. Meola +9 more
wiley +1 more source
Pharmacokinetic aspects and in vitro–in vivo correlation potential for lipid-based formulations
Acta Pharmaceutica Sinica B, 2014 Lipid-based formulations have been an attractive choice among novel drug delivery systems for enhancing the solubility and bioavailability of poorly soluble drugs due to their ability to keep the drug in solubilized state in the gastrointestinal tract ...
Sivacharan Kollipara +1 more
doaj +1 more source
Biorelevant drug release of Metformin dosage forms using complementary in vitro tools
British Journal of Pharmacy, 2017 Drug release from immediate release (IR) and extended release (ER) metformin products was investigated using the Dow Chemical Company’s FloVitroTM biorelevant dissolution instrument.
Karl Box, Patrick O'Dwyer, Hayley Watson
doaj +1 more source
Generalized in vitro-in vivo relationship (IVIVR) model based on artificial neural networks
Drug Design, Development and Therapy, 2013 Aleksander Mendyk,1 Pawel Tuszynski,1 Sebastian Polak,2 Renata Jachowicz1 1Department of Pharmaceutical Technology and Biopharmaceutics, 2Department of Social Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland ...
Mendyk A +3 more
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